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Review

Nanoparticles for the Treatment of Inner Ear Infections

1
“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
2
“M.S. Curie” Clinical Emergency Hospital for Children, 050474 Bucharest, Romania
3
Faculty of Engineering in Foreign Languages, University Politehnica of Bucharest, 060042 Bucharest, Romania
4
Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania
5
Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: Miguel Gisbert-Garzarán and María Vallet-Regí
Nanomaterials 2021, 11(5), 1311; https://doi.org/10.3390/nano11051311
Received: 15 April 2021 / Revised: 12 May 2021 / Accepted: 13 May 2021 / Published: 17 May 2021
(This article belongs to the Special Issue Nanoparticles for Bio-Medical Applications)
The inner ear is sensitive to various infections of viral, bacterial, or fungal origin, which, if left untreated, may lead to hearing loss or progress through the temporal bone and cause intracranial infectious complications. Due to its isolated location, the inner ear is difficult to treat, imposing an acute need for improving current therapeutic approaches. A solution for enhancing antimicrobial treatment performance is the use of nanoparticles. Different inorganic, lipidic, and polymeric-based such particles have been designed, tested, and proven successful in the controlled delivery of medication, improving drug internalization by the targeted cells while reducing the systemic side effects. This paper makes a general presentation of common inner ear infections and therapeutics administration routes, further focusing on newly developed nanoparticle-mediated treatments. View Full-Text
Keywords: inner ear; infections treatment; antimicrobial nanoparticles; drug-delivery systems; potential side effects inner ear; infections treatment; antimicrobial nanoparticles; drug-delivery systems; potential side effects
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MDPI and ACS Style

Gheorghe, D.C.; Niculescu, A.-G.; Bîrcă, A.C.; Grumezescu, A.M. Nanoparticles for the Treatment of Inner Ear Infections. Nanomaterials 2021, 11, 1311. https://doi.org/10.3390/nano11051311

AMA Style

Gheorghe DC, Niculescu A-G, Bîrcă AC, Grumezescu AM. Nanoparticles for the Treatment of Inner Ear Infections. Nanomaterials. 2021; 11(5):1311. https://doi.org/10.3390/nano11051311

Chicago/Turabian Style

Gheorghe, Dan C., Adelina-Gabriela Niculescu, Alexandra C. Bîrcă, and Alexandru M. Grumezescu 2021. "Nanoparticles for the Treatment of Inner Ear Infections" Nanomaterials 11, no. 5: 1311. https://doi.org/10.3390/nano11051311

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