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Article

Investigations of Graphene and Nitrogen-Doped Graphene Enhanced Polycaprolactone 3D Scaffolds for Bone Tissue Engineering

1
Department of Mechanical, Aerospace and Civil Engineering, School of Engineering, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, UK
2
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei E2-514, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Cristina Martín
Nanomaterials 2021, 11(4), 929; https://doi.org/10.3390/nano11040929
Received: 12 March 2021 / Revised: 31 March 2021 / Accepted: 5 April 2021 / Published: 6 April 2021
(This article belongs to the Special Issue Biomedical Applications of Graphene-Based Nanomaterials)
Scaffolds play a key role in tissue engineering applications. In the case of bone tissue engineering, scaffolds are expected to provide both sufficient mechanical properties to withstand the physiological loads, and appropriate bioactivity to stimulate cell growth. In order to further enhance cell–cell signaling and cell–material interaction, electro-active scaffolds have been developed based on the use of electrically conductive biomaterials or blending electrically conductive fillers to non-conductive biomaterials. Graphene has been widely used as functioning filler for the fabrication of electro-active bone tissue engineering scaffolds, due to its high electrical conductivity and potential to enhance both mechanical and biological properties. Nitrogen-doped graphene, a unique form of graphene-derived nanomaterials, presents significantly higher electrical conductivity than pristine graphene, and better surface hydrophilicity while maintaining a similar mechanical property. This paper investigates the synthesis and use of high-performance nitrogen-doped graphene as a functional filler of poly(ɛ-caprolactone) (PCL) scaffolds enabling to develop the next generation of electro-active scaffolds. Compared to PCL scaffolds and PCL/graphene scaffolds, these novel scaffolds present improved in vitro biological performance. View Full-Text
Keywords: additive manufacturing; biomanufacturing; electro-active scaffolds; extrusion process; doping; graphene; polycaprolactone; tissue engineering additive manufacturing; biomanufacturing; electro-active scaffolds; extrusion process; doping; graphene; polycaprolactone; tissue engineering
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MDPI and ACS Style

Wang, W.; Chen, J.-X.; Hou, Y.; Bartolo, P.; Chiang, W.-H. Investigations of Graphene and Nitrogen-Doped Graphene Enhanced Polycaprolactone 3D Scaffolds for Bone Tissue Engineering. Nanomaterials 2021, 11, 929. https://doi.org/10.3390/nano11040929

AMA Style

Wang W, Chen J-X, Hou Y, Bartolo P, Chiang W-H. Investigations of Graphene and Nitrogen-Doped Graphene Enhanced Polycaprolactone 3D Scaffolds for Bone Tissue Engineering. Nanomaterials. 2021; 11(4):929. https://doi.org/10.3390/nano11040929

Chicago/Turabian Style

Wang, Weiguang, Jun-Xiang Chen, Yanhao Hou, Paulo Bartolo, and Wei-Hung Chiang. 2021. "Investigations of Graphene and Nitrogen-Doped Graphene Enhanced Polycaprolactone 3D Scaffolds for Bone Tissue Engineering" Nanomaterials 11, no. 4: 929. https://doi.org/10.3390/nano11040929

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