Next Article in Journal
Supercritical CO2 Assisted Solvothermal Preparation of CoO/Graphene Nanocomposites for High Performance Lithium-Ion Batteries
Previous Article in Journal
Silver Nanowire Synthesis and Strategies for Fabricating Transparent Conducting Electrodes
Previous Article in Special Issue
Surface Modification of Fluorescent Nanodiamonds for Biological Applications
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nanomaterials
Volume 11
Issue 3
10.3390/nano11030695
nanomaterials-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Silk Fibroin Coated Magnesium Oxide Nanospheres: A Biocompatible and Biodegradable Tool for Noninvasive Bioimaging Applications

by
Jitao Li
1,2,
Asma Khalid
2,3,*,
Rajni Verma
2,
Amanda Abraham
3,
Farah Qazi
2,
Xiuxiu Dong
4,
Gaofeng Liang
5 and
Snjezana Tomljenovic-Hanic
2
1
School of Physics and Telecommunications Engineering, Zhoukou Normal University, Zhoukou 466001, China
2
School of Physics, The University of Melbourne, Parkville 3010, Australia
3
ARC Centre of Excellence for Nanoscale BioPhotonics, School of Science, RMIT University, Melbourne, VIC 3001, Australia
4
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
5
Medical College, Henan University of Science and Technology, Luoyang 471023, China
*
Author to whom correspondence should be addressed.
Nanomaterials 2021, 11(3), 695; https://doi.org/10.3390/nano11030695
Submission received: 11 January 2021 / Revised: 25 February 2021 / Accepted: 26 February 2021 / Published: 10 March 2021
(This article belongs to the Special Issue Fluorescent Nanomaterials and Their Applications)
Browse Figures
Review Reports Versions Notes

Abstract

Fluorescent nanoparticles (NPs) have been increasingly studied as contrast agents for better understanding of biological processes at the cellular and molecular level. However, their use as bioimaging tools is strongly dependent on their optical emission as well as their biocompatibility. This work reports the fabrication and characterization of silk fibroin (SF) coated magnesium oxide (MgO) nanospheres, containing oxygen, Cr3+ and V2+ related optical defects, as a nontoxic and biodegradable hybrid platform for bioimaging applications. The MgO-SF spheres demonstrated enhanced emission efficiency compared to noncoated MgO NPs. Furthermore, SF sphere coating was found to overcome agglomeration limitations of the MgO NPs. The hybrid nanospheres were investigated as an in vitro bioimaging tool by recording their cellular uptake, trajectories, and mobility in human skin keratinocytes cells (HaCaT), human glioma cells (U87MG) and breast cancer cells (MCF7). Enhanced cellular uptake and improved intracellular mobilities of MgO-SF spheres compared to MgO NPs was demonstrated in three different cell lines. Validated infrared and bright emission of MgO-SF NP indicate their prospects for in vivo imaging. The results identify the potential of the hybrid MgO-SF nanospheres for bioimaging. This study may also open new avenues to optimize drug delivery through biodegradable silk and provide noninvasive functional imaging feedback on the therapeutic processes through fluorescent MgO.
Keywords: silk fibroin; magnesium oxide; bioimaging; fluorescent nanoparticles silk fibroin; magnesium oxide; bioimaging; fluorescent nanoparticles

Share and Cite

MDPI and ACS Style

Li, J.; Khalid, A.; Verma, R.; Abraham, A.; Qazi, F.; Dong, X.; Liang, G.; Tomljenovic-Hanic, S. Silk Fibroin Coated Magnesium Oxide Nanospheres: A Biocompatible and Biodegradable Tool for Noninvasive Bioimaging Applications. Nanomaterials 2021, 11, 695. https://doi.org/10.3390/nano11030695

AMA Style

Li J, Khalid A, Verma R, Abraham A, Qazi F, Dong X, Liang G, Tomljenovic-Hanic S. Silk Fibroin Coated Magnesium Oxide Nanospheres: A Biocompatible and Biodegradable Tool for Noninvasive Bioimaging Applications. Nanomaterials. 2021; 11(3):695. https://doi.org/10.3390/nano11030695

Chicago/Turabian Style

Li, Jitao, Asma Khalid, Rajni Verma, Amanda Abraham, Farah Qazi, Xiuxiu Dong, Gaofeng Liang, and Snjezana Tomljenovic-Hanic. 2021. "Silk Fibroin Coated Magnesium Oxide Nanospheres: A Biocompatible and Biodegradable Tool for Noninvasive Bioimaging Applications" Nanomaterials 11, no. 3: 695. https://doi.org/10.3390/nano11030695

APA Style

Li, J., Khalid, A., Verma, R., Abraham, A., Qazi, F., Dong, X., Liang, G., & Tomljenovic-Hanic, S. (2021). Silk Fibroin Coated Magnesium Oxide Nanospheres: A Biocompatible and Biodegradable Tool for Noninvasive Bioimaging Applications. Nanomaterials, 11(3), 695. https://doi.org/10.3390/nano11030695

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop