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Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles

Cardno ChemRisk, 6720 S Macadam Ave Suite 150, Portland, OR 97219, USA
Cardno ChemRisk, 30 North LaSalle St Suite 3910, Chicago, IL 60602, USA
NiPERA, 2525 Meridian Parkway, Suite 240, Durham, NC 27713, USA
Cardno ChemRisk, 65 Enterprise Drive Suite 150, Aliso Viejo, CA 92656, USA
Author to whom correspondence should be addressed.
Academic Editor: Jose L. Luque-Garcia
Nanomaterials 2021, 11(3), 642;
Received: 19 January 2021 / Revised: 22 February 2021 / Accepted: 2 March 2021 / Published: 5 March 2021
(This article belongs to the Special Issue Advances in Toxicity of Nanoparticles)
The exceptional physical and chemical properties of nickel nanomaterials have been exploited in a range of applications such as electrical conductors, batteries, and biomaterials. However, it has been suggested that these unique properties may allow for increased bioavailability, bio-reactivity, and potential adverse health effects. Thus, the purpose of this review was to critically evaluate data regarding the toxicity of oxidic nickel nanoparticles (nickel oxide (NiO) and nickel hydroxide (Ni(OH)2) nanoparticles) with respect to: (1) physico-chemistry properties; (2) nanomaterial characterization in the defined delivery media; (3) appropriateness of model system and translation to potential human effects; (4) biodistribution, retention, and clearance; (5) routes and relevance of exposure; and (6) current research data gaps and likely directions of future research. Inhalation studies were prioritized for review as this represents a potential exposure route in humans. Oxidic nickel particle size ranged from 5 to 100 nm in the 60 studies that were identified. Inflammatory responses induced by exposure of oxidic nickel nanoparticles via inhalation in rodent studies was characterized as acute in nature and only displayed chronic effects after relatively large (high concentration and long duration) exposures. Furthermore, there is no evidence, thus far, to suggest that the effects induced by oxidic nickel nanoparticles are related to preneoplastic events. There are some data to suggest that nano- and micron-sized NiO particles follow a similar dose response when normalized to surface area. However, future experiments need to be conducted to better characterize the exposure–dose–response relationship according to specific surface area and reactivity as a dose metric, which drives particle dissolution and potential biological responses. View Full-Text
Keywords: nickel oxide nanoparticles; oxidic nickel nanoparticles; toxicity; nanotoxicity nickel oxide nanoparticles; oxidic nickel nanoparticles; toxicity; nanotoxicity
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MDPI and ACS Style

More, S.L.; Kovochich, M.; Lyons-Darden, T.; Taylor, M.; Schulte, A.M.; Madl, A.K. Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles. Nanomaterials 2021, 11, 642.

AMA Style

More SL, Kovochich M, Lyons-Darden T, Taylor M, Schulte AM, Madl AK. Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles. Nanomaterials. 2021; 11(3):642.

Chicago/Turabian Style

More, Sharlee L., Michael Kovochich, Tara Lyons-Darden, Michael Taylor, Alexandra M. Schulte, and Amy K. Madl. 2021. "Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles" Nanomaterials 11, no. 3: 642.

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