Next Article in Journal
Focalization Performance Study of a Novel Bulk Acoustic Wave Device
Next Article in Special Issue
Tween® Preserves Enzyme Activity and Stability in PLGA Nanoparticles
Previous Article in Journal
Photophysical and Electro-Optical Properties of Copolymers Bearing Blue and Red Chromophores for Single-Layer White OLEDs
Previous Article in Special Issue
Data-Driven Modeling of the Cellular Pharmacokinetics of Degradable Chitosan-Based Nanoparticles

Iron-Doped ZnO Nanoparticles as Multifunctional Nanoplatforms for Theranostics

Department of Applied Science and Technology, Politecnico di Torino, Duca degli Abruzzi 24, 10129 Turin, Italy
Author to whom correspondence should be addressed.
Academic Editor: Pablo Botella
Nanomaterials 2021, 11(10), 2628;
Received: 9 September 2021 / Revised: 27 September 2021 / Accepted: 1 October 2021 / Published: 6 October 2021
Zinc oxide nanoparticles (ZnO NPs) are currently among the most promising nanomaterials for theranostics. However, they suffer from some drawbacks that could prevent their application in nanomedicine as theranostic agents. The doping of ZnO NPs can be effectively exploited to enhance the already-existing ZnO properties and introduce completely new functionalities in the doped material. Herein, we propose a novel synthetic approach for iron-doped ZnO (Fe:ZnO) NPs as a multifunctional theranostic nanoplatform aimed at cancer cell treatment. Pure ZnO and Fe:ZnO NPs, with two different levels of iron doping, were synthesized by a rapid wet-chemical method and analyzed in terms of morphology, crystal structure and chemical composition. Interestingly, Fe:ZnO NPs featured bioimaging potentialities thanks to superior optical properties and novel magnetic responsiveness. Moreover, iron doping provides a way to enhance the electromechanical behavior of the NPs, which are then expected to show enhanced therapeutic functionalities. Finally, the intrinsic therapeutic potentialities of the NPs were tested in terms of cytotoxicity and cellular uptake with both healthy B lymphocytes and cancerous Burkitt’s lymphoma cells. Furthermore, their biocompatibility was tested with a pancreatic ductal adenocarcinoma cell line (BxPC-3), where the novel properties of the proposed iron-doped ZnO NPs can be potentially exploited for theranostics. View Full-Text
Keywords: ZnO; iron doping; piezoelectricity; magnetic NPs; theranostics; cancer treatment ZnO; iron doping; piezoelectricity; magnetic NPs; theranostics; cancer treatment
Show Figures

Graphical abstract

MDPI and ACS Style

Carofiglio, M.; Laurenti, M.; Vighetto, V.; Racca, L.; Barui, S.; Garino, N.; Gerbaldo, R.; Laviano, F.; Cauda, V. Iron-Doped ZnO Nanoparticles as Multifunctional Nanoplatforms for Theranostics. Nanomaterials 2021, 11, 2628.

AMA Style

Carofiglio M, Laurenti M, Vighetto V, Racca L, Barui S, Garino N, Gerbaldo R, Laviano F, Cauda V. Iron-Doped ZnO Nanoparticles as Multifunctional Nanoplatforms for Theranostics. Nanomaterials. 2021; 11(10):2628.

Chicago/Turabian Style

Carofiglio, Marco, Marco Laurenti, Veronica Vighetto, Luisa Racca, Sugata Barui, Nadia Garino, Roberto Gerbaldo, Francesco Laviano, and Valentina Cauda. 2021. "Iron-Doped ZnO Nanoparticles as Multifunctional Nanoplatforms for Theranostics" Nanomaterials 11, no. 10: 2628.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop