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Effects of Airborne Nanoparticles on the Nervous System: Amyloid Protein Aggregation, Neurodegeneration and Neurodegenerative Diseases

IUF—Leibniz Research Institute for Environmental Medicine gGmbH, Heinrich-Heine-University, 40225 Duesseldorf, Germany
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Nanomaterials 2020, 10(7), 1349; https://doi.org/10.3390/nano10071349
Received: 7 June 2020 / Revised: 3 July 2020 / Accepted: 7 July 2020 / Published: 10 July 2020
(This article belongs to the Special Issue Toxicology and Biocompatibility of Nanomaterials)
How the environment contributes to neurodegenerative diseases such as Alzheimer’s is not well understood. In recent years, science has found augmenting evidence that nano-sized particles generated by transport (e.g., fuel combustion, tire wear and brake wear) may promote Alzheimer’s disease (AD). Individuals residing close to busy roads are at higher risk of developing AD, and nanomaterials that are specifically generated by traffic-related processes have been detected in human brains. Since AD represents a neurodegenerative disease characterized by amyloid protein aggregation, this review summarizes our current knowledge on the amyloid-generating propensity of traffic-related nanomaterials. Certain nanoparticles induce the amyloid aggregation of otherwise soluble proteins in in vitro laboratory settings, cultured neuronal cells and vertebrate or invertebrate animal models. We discuss the challenges for future studies, namely, strategies to connect the wet laboratory with the epidemiological data in order to elucidate the molecular bio-interactions of airborne nanomaterials and their effects on human health. View Full-Text
Keywords: air pollution; Alzheimer’s disease; amyloid; Caenorhabditis elegans; COVID-19; dementia; neurotoxicology; particulate matter; serotonin; tire wear air pollution; Alzheimer’s disease; amyloid; Caenorhabditis elegans; COVID-19; dementia; neurotoxicology; particulate matter; serotonin; tire wear
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MDPI and ACS Style

von Mikecz, A.; Schikowski, T. Effects of Airborne Nanoparticles on the Nervous System: Amyloid Protein Aggregation, Neurodegeneration and Neurodegenerative Diseases. Nanomaterials 2020, 10, 1349. https://doi.org/10.3390/nano10071349

AMA Style

von Mikecz A, Schikowski T. Effects of Airborne Nanoparticles on the Nervous System: Amyloid Protein Aggregation, Neurodegeneration and Neurodegenerative Diseases. Nanomaterials. 2020; 10(7):1349. https://doi.org/10.3390/nano10071349

Chicago/Turabian Style

von Mikecz, Anna, and Tamara Schikowski. 2020. "Effects of Airborne Nanoparticles on the Nervous System: Amyloid Protein Aggregation, Neurodegeneration and Neurodegenerative Diseases" Nanomaterials 10, no. 7: 1349. https://doi.org/10.3390/nano10071349

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