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Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications

Chair and Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, ul. Dębinki 1, 80-211 Gdansk, Poland
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Nanomaterials 2020, 10(4), 658; https://doi.org/10.3390/nano10040658
Received: 9 March 2020 / Revised: 29 March 2020 / Accepted: 30 March 2020 / Published: 1 April 2020
(This article belongs to the Section Biology and Medicines)
Materials sized 1–100 nm are the nanotechnology’s field of interest. Because of the unique properties such as the ability to penetrate biological barriers and a high surface to volume ratio, nanoparticles (NPs) are a powerful tool to be used in medicine and industry. This review discusses the role of nanotechnology in bone-related issues: osteosarcoma (bone cancer), the biocompatibility of the implants and implant-related infections. In cancer therapy, NPs can be used as (I) cytotoxic agents, (II) drug delivery platforms and (III) in thermotherapy. In implant-related issues, NPs can be used as (I) antimicrobial agents and (II) adjuvants to increase the biocompatibility of implant surface. Properties of NPs depend on (I) the type of NPs, (II) their size, (III) shape, (IV) concentration, (V) incubation time, (VI) functionalization and (VII) capping agent type. View Full-Text
Keywords: nanotechnology; nanoparticles; osteosarcoma; antimicrobial properties; nanotoxicology; biocompatibility; bone diseases; implant-related infections nanotechnology; nanoparticles; osteosarcoma; antimicrobial properties; nanotoxicology; biocompatibility; bone diseases; implant-related infections
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Steckiewicz, K.P.; Inkielewicz-Stepniak, I. Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications. Nanomaterials 2020, 10, 658.

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