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Open AccessFeature PaperArticle

Immunomodulatory Potential of Differently-Terminated Ultra-Small Silicon Carbide Nanoparticles

1
Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 323 00 Pilsen, Czech Republic
2
Wigner Research Centre for Physics, 1121 Budapest, Hungary
3
Department of Atomic Physics, Budapest University of Technology and Economics, 1111 Budapest, Hungary
4
Department of Chemical Physics and Optics, Faculty of Mathematics and Physics, Charles University, 121 16 Prague, Czech Republic
5
Institute of Pathological Physiology, 1st Faculty of Medicine, Charles University, 128 53 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(3), 573; https://doi.org/10.3390/nano10030573
Received: 2 March 2020 / Revised: 18 March 2020 / Accepted: 19 March 2020 / Published: 22 March 2020
(This article belongs to the Section Biology and Medicines)
Ultra-small nanoparticles with sizes comparable to those of pores in the cellular membrane possess significant potential for application in the field of biomedicine. Silicon carbide ultra-small nanoparticles with varying surface termination were tested for the biological system represented by different human cells (using a human osteoblastic cell line as the reference system and a monocyte/macrophage cell line as immune cells). The three tested nanoparticle surface terminations resulted in the observation of different effects on cell metabolic activity. These effects were mostly noticeable in cases of monocytic cells, where each type of particle caused a completely different response (‘as-prepared’ particles, i.e., were highly cytotoxic, –OH terminated particles slightly increased the metabolic activity, while –NH2 terminated particles caused an almost doubled metabolic activity) after 24 h of incubation. Subsequently, the release of cytokines from such treated monocytes and their differentiation into activated cells was determined. The results revealed the potential modulation of immune cell behavior following stimulation with particular ultra-small nanoparticles, thus opening up new fields for novel silicon carbide nanoparticle biomedical applications. View Full-Text
Keywords: nanoparticles; silicon carbide; cytotoxicity; immune cells; osteoblasts nanoparticles; silicon carbide; cytotoxicity; immune cells; osteoblasts
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MDPI and ACS Style

Bělinová, T.; Machová, I.; Beke, D.; Fučíková, A.; Gali, A.; Humlová, Z.; Valenta, J.; Hubálek Kalbáčová, M. Immunomodulatory Potential of Differently-Terminated Ultra-Small Silicon Carbide Nanoparticles. Nanomaterials 2020, 10, 573.

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