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Open AccessArticle

Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy

by Lin-Fei Chen 1,2,†, Pei-Yao Xu 1,2,†, Chao-Ping Fu 2,3, Ranjith Kumar Kankala 1,2,3, Ai-Zheng Chen 1,2,3,* and Shi-Bin Wang 2,3,*
1
Department of Chemical Engineering and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, China
2
Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China
3
Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen 361021, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(2), 322; https://doi.org/10.3390/nano10020322
Received: 14 January 2020 / Revised: 4 February 2020 / Accepted: 11 February 2020 / Published: 13 February 2020
(This article belongs to the Special Issue Anti-Cancer, Biochemical and Immunological Activity of Nanoparticles )
Due to its hydrophobicity, fisetin (FIS) often suffers from several limitations in terms of its applicability during the fabrication of pharmaceutical formulations. To overcome this intrinsic limitation of hydrophobicity, we demonstrate here the generation of poly (vinyl pyrrolidone) (PVP)-encapsulated FIS nanoparticles (FIS-PVP NPs) utilizing a supercritical antisolvent (SAS) method to enhance its aqueous solubility and substantial therapeutic effects. In this context, the effects of various processing and formulation parameters, including the solvent/antisolvent ratio, drug/polymer (FIS/PVP) mass ratio, and solution flow rate, on the eventual particle size as well as on distribution were investigated using a 23 factorial experimental design. Notably, the FIS/PVP mass ratio significantly affected the morphological attributes of the resultant particles. Initially, the designed constructs were characterized systematically using various techniques (e.g., chemical functionalities were examined with Fourier-transform infrared (FTIR) spectroscopy, and physical states were examined with X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) techniques). In addition, drug release as well as cytotoxicity evaluations in vitro indicated that the nanosized polymer-coated particles showed augmented performance efficiency compared to the free drug, which was attributable to the improvement in the dissolution rate of the FIS-PVP NPs due to their small size, facilitating a higher surface area over the raw form of FIS. Our findings show that the designed SAS process-assisted nanoconstructs with augmented bioavailability, have great potential for applications in pharmaceutics. View Full-Text
Keywords: supercritical fluid technology; fisetin; nanofabrication; antitumor supercritical fluid technology; fisetin; nanofabrication; antitumor
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MDPI and ACS Style

Chen, L.-F.; Xu, P.-Y.; Fu, C.-P.; Kankala, R.K.; Chen, A.-Z.; Wang, S.-B. Fabrication of Supercritical Antisolvent (SAS) Process-Assisted Fisetin-Encapsulated Poly (Vinyl Pyrrolidone) (PVP) Nanocomposites for Improved Anticancer Therapy. Nanomaterials 2020, 10, 322.

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