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Article

Highly Efficient Antimicrobial Activity of CuxFeyOz Nanoparticles against Important Human Pathogens

1
School of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA
2
Department of Physics and Astronomy, University of Georgia, Athens, GA 30602, USA
3
Department of Microbiology, University of Georgia, Athens, GA 30602, USA
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Department of Food Science & Technology, University of Georgia, Griffin, GA 30223, USA
5
Department of Materials Science & Engineering, University of Toronto, Toronto, ON M5S 1A1, Canada
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Department of Microbiology and Immunology, University of Mississippi, Jackson, MS 39216, USA
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(11), 2294; https://doi.org/10.3390/nano10112294
Received: 24 October 2020 / Revised: 15 November 2020 / Accepted: 17 November 2020 / Published: 20 November 2020
(This article belongs to the Special Issue Nanomaterials for Biomedical Applications)
The development of innovative antimicrobial materials is crucial in thwarting infectious diseases caused by microbes, as drug-resistant pathogens are increasing in both number and capacity to detoxify the antimicrobial drugs used today. An ideal antimicrobial material should inhibit a wide variety of bacteria in a short period of time, be less or not toxic to normal cells, and the fabrication or synthesis process should be cheap and easy. We report a one-step microwave-assisted hydrothermal synthesis of mixed composite CuxFeyOz (Fe2O3/Cu2O/CuO/CuFe2O) nanoparticles (NPs) as an excellent antimicrobial material. The 1 mg/mL CuxFeyOz NPs with the composition 36% CuFeO2, 28% Cu2O and 36% Fe2O3 have a general antimicrobial activity greater than 5 log reduction within 4 h against nine important human pathogenic bacteria (including drug-resistant bacteria as well as Gram-positive and Gram-negative strains). For example, they induced a >9 log reduction in Escherichia coli B viability after 15 min of incubation, and an ~8 log reduction in multidrug-resistant Klebsiella pneumoniae after 4 h incubation. Cytotoxicity tests against mouse fibroblast cells showed about 74% viability when exposed to 1 mg/mL CuxFeyOz NPs for 24 h, compared to the 20% viability for 1 mg/mL pure Cu2O NPs synthesized by the same method. These results show that the CuxFeyOz composite NPs are a highly efficient, low-toxicity and cheap antimicrobial material that has promising potential for applications in medical and food safety. View Full-Text
Keywords: antimicrobial materials; inorganic nanomaterials; drug-resistant bacteria; metal oxides; copper iron oxides; copper oxide; cuprous oxide antimicrobial materials; inorganic nanomaterials; drug-resistant bacteria; metal oxides; copper iron oxides; copper oxide; cuprous oxide
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MDPI and ACS Style

Zhu, L.; Pearson, D.W.; Benoit, S.L.; Xie, J.; Pant, J.; Yang, Y.; Mondal, A.; Handa, H.; Howe, J.Y.; Hung, Y.-C.; Vidal, J.E.; Maier, R.J.; Zhao, Y. Highly Efficient Antimicrobial Activity of CuxFeyOz Nanoparticles against Important Human Pathogens. Nanomaterials 2020, 10, 2294. https://doi.org/10.3390/nano10112294

AMA Style

Zhu L, Pearson DW, Benoit SL, Xie J, Pant J, Yang Y, Mondal A, Handa H, Howe JY, Hung Y-C, Vidal JE, Maier RJ, Zhao Y. Highly Efficient Antimicrobial Activity of CuxFeyOz Nanoparticles against Important Human Pathogens. Nanomaterials. 2020; 10(11):2294. https://doi.org/10.3390/nano10112294

Chicago/Turabian Style

Zhu, Lu, David W. Pearson, Stéphane L. Benoit, Jing Xie, Jitendra Pant, Yanjun Yang, Arnab Mondal, Hitesh Handa, Jane Y. Howe, Yen-Con Hung, Jorge E. Vidal, Robert J. Maier, and Yiping Zhao. 2020. "Highly Efficient Antimicrobial Activity of CuxFeyOz Nanoparticles against Important Human Pathogens" Nanomaterials 10, no. 11: 2294. https://doi.org/10.3390/nano10112294

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