A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications
Abstract
:1. Introduction
2. Biodegradable and Non-Biodegradable Polymer Nanomaterials (PNM): General Properties
2.1. Biodegradable Polymer Properties
- (1)
- In situ administration of formulations
- (2)
- On-demand delivery of the molecular targeted agent
- (3)
- The fact that a targeted agent can be combined with radiotherapy and immunotherapy
- (4)
- The use of FDA approved biodegradable polymers [35]
2.2. Non-Biodegradable Polymer Properties
3. Chitosan-Based Nanoparticles
4. Alginate-Based Nanoparticles
5. Albumin-Based Nanoparticles
6. Hydroxyapatite-Based Nanoparticles
7. Hyaluronic Acid-Based Nanoparticles
8. Conclusions
Funding
Conflicts of Interest
References
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Nanoparticle Drug Delivery System |
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Polymeric carriers |
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Polymer/Modified Polymer | Preparation Method | Model Drug |
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Chitosan–folic acid | Ionic gelation | 5-flurouracil |
Chitosan/alginate and solid lipid NPs | Ionic gelation | Ciprofloxacin |
PVA/chitosan-gelation | Electrospinning method | Erythromycin |
Alginate calcium carbonate | Co-precipitation | Paclitaxel |
PEGylated albumin | RAFT polymerization | Lysozyme |
Bovine serum albumin | Multistep process | Temozolomide |
Egg albumin | Desolvation method | Curcumin |
PEG-modified human serum albumin | Solid dispersion technology | Paclitaxel |
Advantages | Disadvantages | Biomedical Applications | Method of Preparation |
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Bioactive (hydration shell) | Strong hydration shell, ionic surface, fragile | Drug delivery system, tissue engineering’ implants | Wet method, dry method, high-temperature process |
Ease of modification and surface functionalization | Precipitation and turbid solution | - | - |
Good attachment to polymers | Surface corona formation, aggregation | - | - |
Ease of composite formation | Dispersity in chemical composition, size and shape polymorphism | - | - |
Biodegradable, biocompatibility | High pH sensitivity and solubility | - | - |
Self-assembly | Low stability | - | - |
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Idrees, H.; Zaidi, S.Z.J.; Sabir, A.; Khan, R.U.; Zhang, X.; Hassan, S.-u. A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications. Nanomaterials 2020, 10, 1970. https://doi.org/10.3390/nano10101970
Idrees H, Zaidi SZJ, Sabir A, Khan RU, Zhang X, Hassan S-u. A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications. Nanomaterials. 2020; 10(10):1970. https://doi.org/10.3390/nano10101970
Chicago/Turabian StyleIdrees, Humaira, Syed Zohaib Javaid Zaidi, Aneela Sabir, Rafi Ullah Khan, Xunli Zhang, and Sammer-ul Hassan. 2020. "A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications" Nanomaterials 10, no. 10: 1970. https://doi.org/10.3390/nano10101970