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Open AccessArticle

Hadron Therapy, Magnetic Nanoparticles and Hyperthermia: A Promising Combined Tool for Pancreatic Cancer Treatment

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Dipartimento di Fisica and INFN, Università degli Studi di Pavia, 27100 Pavia, Italy
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Dipartimento di Chimica, Università di Firenze and INSTM, 50019 Sesto Fiorentino (FI), Italy
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Dipartimento di Scienze and INFN, Università Roma Tre, 00146 Roma, Italy
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Dipartimento di Fisica and INFN, Università degli Studi di Milano, 20133 Milano, Italy
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Fondazione CNAO, 27100 Pavia, Italy
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Dipartimento di Fisica, Università degli Studi di Milano and INFN, Lab. LASA, 20090 Segrate (MI), Italy
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ICCOM-CNR, 50019 Sesto Fiorentino (FI), Italy
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C.I.Ma.I.Na., Centro Interdisciplinare Materiali e Interfacce Nanostrutturati, 20133 Milano, Italy
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Fondazione IRCSS Istituto Nazionale dei tumori, 20133 Milano, Italy
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INFN, Sezione di Firenze, 50019 Sesto Fiorentino (FI), Italy
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Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(10), 1919; https://doi.org/10.3390/nano10101919
Received: 31 August 2020 / Revised: 16 September 2020 / Accepted: 18 September 2020 / Published: 25 September 2020
(This article belongs to the Special Issue Nanomaterials for Drug Delivery and Cancer Therapy)
A combination of carbon ions/photons irradiation and hyperthermia as a novel therapeutic approach for the in-vitro treatment of pancreatic cancer BxPC3 cells is presented. The radiation doses used are 0–2 Gy for carbon ions and 0–7 Gy for 6 MV photons. Hyperthermia is realized via a standard heating bath, assisted by magnetic fluid hyperthermia (MFH) that utilizes magnetic nanoparticles (MNPs) exposed to an alternating magnetic field of amplitude 19.5 mTesla and frequency 109.8 kHz. Starting from 37 °C, the temperature is gradually increased and the sample is kept at 42 °C for 30 min. For MFH, MNPs with a mean diameter of 19 nm and specific absorption rate of 110 ± 30 W/gFe3o4 coated with a biocompatible ligand to ensure stability in physiological media are used. Irradiation diminishes the clonogenic survival at an extent that depends on the radiation type, and its decrease is amplified both by the MNPs cellular uptake and the hyperthermia protocol. Significant increases in DNA double-strand breaks at 6 h are observed in samples exposed to MNP uptake, treated with 0.75 Gy carbon-ion irradiation and hyperthermia. The proposed experimental protocol, based on the combination of hadron irradiation and hyperthermia, represents a first step towards an innovative clinical option for pancreatic cancer. View Full-Text
Keywords: hadron therapy; magnetic nanoparticles; hyperthermia; nanomaterials; magnetic fluid hyperthermia; pancreatic cancer hadron therapy; magnetic nanoparticles; hyperthermia; nanomaterials; magnetic fluid hyperthermia; pancreatic cancer
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Brero, F.; Albino, M.; Antoccia, A.; Arosio, P.; Avolio, M.; Berardinelli, F.; Bettega, D.; Calzolari, P.; Ciocca, M.; Corti, M.; Facoetti, A.; Gallo, S.; Groppi, F.; Guerrini, A.; Innocenti, C.; Lenardi, C.; Locarno, S.; Manenti, S.; Marchesini, R.; Mariani, M.; Orsini, F.; Pignoli, E.; Sangregorio, C.; Veronese, I.; Lascialfari, A. Hadron Therapy, Magnetic Nanoparticles and Hyperthermia: A Promising Combined Tool for Pancreatic Cancer Treatment. Nanomaterials 2020, 10, 1919.

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