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Open AccessArticle

Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene

1
Department of Chemistry and Smalley-Curl Institute, Rice University, 6100 Main St, Houston, TX 77005, USA
2
Department of Cancer Systems Imaging, MD Anderson Cancer Center, 1881 East Rd, Houston, TX 77054, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Present Address: Department of Chemistry, University of Pittsburgh, 3960 Forbes Ave, Pittsburgh, PA 15260, USA.
Nanomaterials 2020, 10(1), 143; https://doi.org/10.3390/nano10010143
Received: 11 December 2019 / Revised: 31 December 2019 / Accepted: 8 January 2020 / Published: 13 January 2020
Carbon nanoparticles have consistently been of great interest in medicine. However, there are currently no clinical materials based on carbon nanoparticles, due to inconsistent biodistribution and excretion data. In this work, we have synthesized a novel C60 derivative with a metal chelating agent (1,4,7-Triazacyclononane-1,4,7-triacetic acid; NOTA) covalently bound to the C60 cage and radiolabeled with copper-64 (t1/2 = 12.7 h). Biodistribution of the material was assessed in vivo using positron emission tomography (PET). Bingel-Hirsch chemistry was employed to functionalize the fullerene cage with highly water-soluble serinolamide groups allowing this new C60 conjugate to clear quickly from mice almost exclusively through the kidneys. Comparing the present results to the larger context of reports of biocompatible fullerene derivatives, this work offers an important evaluation of the in vivo biodistribution, using experimental evidence to establish functionalization guidelines for future C60-based biomedical platforms. View Full-Text
Keywords: fullerene; serinolamide; biodistribution; pharmacokinetics; PET fullerene; serinolamide; biodistribution; pharmacokinetics; PET
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MDPI and ACS Style

Zaibaq, N.G.; Pollard, A.C.; Collins, M.J.; Pisaneschi, F.; Pagel, M.D.; Wilson, L.J. Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene. Nanomaterials 2020, 10, 143.

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