Next Article in Journal
The Effects of Metal Complexes of Nano-Graphene Oxide to Thermal Decomposition of FOX-7
Previous Article in Journal
Intrinsic Control in Defects Density for Improved ZnO Nanorod-Based UV Sensor Performance
Open AccessArticle

Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene

Department of Chemistry and Smalley-Curl Institute, Rice University, 6100 Main St, Houston, TX 77005, USA
Department of Cancer Systems Imaging, MD Anderson Cancer Center, 1881 East Rd, Houston, TX 77054, USA
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Present Address: Department of Chemistry, University of Pittsburgh, 3960 Forbes Ave, Pittsburgh, PA 15260, USA.
Nanomaterials 2020, 10(1), 143;
Received: 11 December 2019 / Revised: 31 December 2019 / Accepted: 8 January 2020 / Published: 13 January 2020
Carbon nanoparticles have consistently been of great interest in medicine. However, there are currently no clinical materials based on carbon nanoparticles, due to inconsistent biodistribution and excretion data. In this work, we have synthesized a novel C60 derivative with a metal chelating agent (1,4,7-Triazacyclononane-1,4,7-triacetic acid; NOTA) covalently bound to the C60 cage and radiolabeled with copper-64 (t1/2 = 12.7 h). Biodistribution of the material was assessed in vivo using positron emission tomography (PET). Bingel-Hirsch chemistry was employed to functionalize the fullerene cage with highly water-soluble serinolamide groups allowing this new C60 conjugate to clear quickly from mice almost exclusively through the kidneys. Comparing the present results to the larger context of reports of biocompatible fullerene derivatives, this work offers an important evaluation of the in vivo biodistribution, using experimental evidence to establish functionalization guidelines for future C60-based biomedical platforms. View Full-Text
Keywords: fullerene; serinolamide; biodistribution; pharmacokinetics; PET fullerene; serinolamide; biodistribution; pharmacokinetics; PET
Show Figures

Graphical abstract

MDPI and ACS Style

Zaibaq, N.G.; Pollard, A.C.; Collins, M.J.; Pisaneschi, F.; Pagel, M.D.; Wilson, L.J. Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene. Nanomaterials 2020, 10, 143.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop