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Open AccessReview

Fabrication and Plasma Modification of Nanofibrous Tissue Engineering Scaffolds

Research Unit Plasma Technology (RUPT), Department of Applied Physics, Ghent University, Sint-Pietersnieuwstraat 41, B4, B-9000 Ghent, Belgium
Department of Biomedical Engineering, University of Manitoba, Winnipeg, MB R3E 0Z3, Canada
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(1), 119;
Received: 21 November 2019 / Revised: 13 December 2019 / Accepted: 21 December 2019 / Published: 8 January 2020
This paper provides a comprehensive overview of nanofibrous structures for tissue engineering purposes and the role of non-thermal plasma technology (NTP) within this field. Special attention is first given to nanofiber fabrication strategies, including thermally-induced phase separation, molecular self-assembly, and electrospinning, highlighting their strengths, weaknesses, and potentials. The review then continues to discuss the biodegradable polyesters typically employed for nanofiber fabrication, while the primary focus lies on their applicability and limitations. From thereon, the reader is introduced to the concept of NTP and its application in plasma-assisted surface modification of nanofibrous scaffolds. The final part of the review discusses the available literature on NTP-modified nanofibers looking at the impact of plasma activation and polymerization treatments on nanofiber wettability, surface chemistry, cell adhesion/proliferation and protein grafting. As such, this review provides a complete introduction into NTP-modified nanofibers, while aiming to address the current unexplored potentials left within the field.
Keywords: electrospun nanofibers; non-thermal plasma treatment; tissue engineering electrospun nanofibers; non-thermal plasma treatment; tissue engineering
MDPI and ACS Style

Asadian, M.; Chan, K.V.; Norouzi, M.; Grande, S.; Cools, P.; Morent, R.; De Geyter, N. Fabrication and Plasma Modification of Nanofibrous Tissue Engineering Scaffolds. Nanomaterials 2020, 10, 119.

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