Next Article in Journal
Antimicrobial Monomers for Polymeric Dental Restoratives: Cytotoxicity and Physicochemical Properties
Next Article in Special Issue
Short-Term Degradation of Bi-Component Electrospun Fibers: Qualitative and Quantitative Evaluations via AFM Analysis
Previous Article in Journal / Special Issue
Modulation of Osteoclast Interactions with Orthopaedic Biomaterials
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessFeature PaperReview
J. Funct. Biomater. 2018, 9(1), 19;

A Critical Review on Metallic Glasses as Structural Materials for Cardiovascular Stent Applications

Institute of High Performance Computing, A*STAR, Singapore 138632, Singapore
Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089-0241, USA
Department of Materials Science and Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
Authors to whom correspondence should be addressed.
Received: 29 December 2017 / Revised: 5 February 2018 / Accepted: 22 February 2018 / Published: 27 February 2018
(This article belongs to the Special Issue Journal of Functional Biomaterials: Feature Papers 2016)
PDF [6242 KB, uploaded 27 February 2018]


Functional and mechanical properties of novel biomaterials must be carefully evaluated to guarantee long-term biocompatibility and structural integrity of implantable medical devices. Owing to the combination of metallic bonding and amorphous structure, metallic glasses (MGs) exhibit extraordinary properties superior to conventional crystalline metallic alloys, placing them at the frontier of biomaterials research. MGs have potential to improve corrosion resistance, biocompatibility, strength, and longevity of biomedical implants, and hence are promising materials for cardiovascular stent applications. Nevertheless, while functional properties and biocompatibility of MGs have been widely investigated and validated, a solid understanding of their mechanical performance during different stages in stent applications is still scarce. In this review, we provide a brief, yet comprehensive account on the general aspects of MGs regarding their formation, processing, structure, mechanical, and chemical properties. More specifically, we focus on the additive manufacturing (AM) of MGs, their outstanding high strength and resilience, and their fatigue properties. The interconnection between processing, structure and mechanical behaviour of MGs is highlighted. We further review the main categories of cardiovascular stents, the required mechanical properties of each category, and the conventional materials have been using to address these requirements. Then, we bridge between the mechanical requirements of stents, structural properties of MGs, and the corresponding stent design caveats. In particular, we discuss our recent findings on the feasibility of using MGs in self-expandable stents where our results show that a metallic glass based aortic stent can be crimped without mechanical failure. We further justify the safe deployment of this stent in human descending aorta. It is our intent with this review to inspire biodevice developers toward the realization of MG-based stents. View Full-Text
Keywords: metallic glass; fatigue; additive manufacturing; stent; nitinol; heart valve; finite element analysis metallic glass; fatigue; additive manufacturing; stent; nitinol; heart valve; finite element analysis

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Jafary-Zadeh, M.; Praveen Kumar, G.; Branicio, P.S.; Seifi, M.; Lewandowski, J.J.; Cui, F. A Critical Review on Metallic Glasses as Structural Materials for Cardiovascular Stent Applications. J. Funct. Biomater. 2018, 9, 19.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top