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Open AccessFeature PaperReview

Carbon Nano-Allotrope/Magnetic Nanoparticle Hybrid Nanomaterials as T2 Contrast Agents for Magnetic Resonance Imaging Applications

Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, USA
J. Funct. Biomater. 2018, 9(1), 16; https://doi.org/10.3390/jfb9010016
Received: 9 January 2018 / Revised: 28 January 2018 / Accepted: 1 February 2018 / Published: 6 February 2018
(This article belongs to the Special Issue Journal of Functional Biomaterials: Feature Papers 2016)
Magnetic resonance imaging (MRI) is the most powerful tool for deep penetration and high-quality 3D imaging of tissues with anatomical details. However, the sensitivity of the MRI technique is not as good as that of the radioactive or optical imaging methods. Carbon-based nanomaterials have attracted significant attention in biomaterial research in recent decades due to their unique physical properties, versatile functionalization chemistry, as well as excellent biological compatibility. Researchers have employed various carbon nano-allotropes to develop hybrid MRI contrast agents for improved sensitivity. This review summarizes the new research progresses in carbon-based hybrid MRI contrast agents, especially those reported in the past five years. The review will only focus on T2-weighted MRI agents and will be categorized by the different carbon allotrope types and magnetic components. Considering the strong trend in recent bio-nanotechnology research towards multifunctional diagnosis and therapy, carbon-based MRI contrast agents integrated with other imaging modalities or therapeutic functions are also covered. View Full-Text
Keywords: MRI; T2-weighted; contrast agent; carbon nanomaterials; carbon nanotubes; graphene; magnetic nanoparticles; drug delivery; theranostic; imaging MRI; T2-weighted; contrast agent; carbon nanomaterials; carbon nanotubes; graphene; magnetic nanoparticles; drug delivery; theranostic; imaging
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Gao, Y. Carbon Nano-Allotrope/Magnetic Nanoparticle Hybrid Nanomaterials as T2 Contrast Agents for Magnetic Resonance Imaging Applications. J. Funct. Biomater. 2018, 9, 16.

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