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J. Funct. Biomater. 2014, 5(4), 288-295;

Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation

Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 3325, Los Angeles, CA 90095, USA
Department of Biology, College of Arts and Sciences, Syracuse University, Syracuse, NY 13244, USA
School of Medicine, St. George's University, Grenada, West Indies
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 24 August 2014 / Revised: 19 November 2014 / Accepted: 25 November 2014 / Published: 12 December 2014
(This article belongs to the Special Issue Blood Substitutes)
Full-Text   |   PDF [191 KB, uploaded 12 December 2014]


For many decades, Hemoglobin-based oxygen carriers (HBOCs) have been central in the development of resuscitation agents that might provide oxygen delivery in addition to simple volume expansion. Since 80% of the world population lives in areas where fresh blood products are not available, the application of these new solutions may prove to be highly beneficial (Kim and Greenburg 2006). Many improvements have been made to earlier generation HBOCs, but various concerns still remain, including coagulopathy, nitric oxide scavenging, platelet interference and decreased calcium concentration secondary to volume expansion (Jahr et al. 2013). This review will summarize the current challenges faced in developing HBOCs that may be used clinically, in order to guide future research efforts in the field. View Full-Text
Keywords: HBOC; blood substitute; resuscitation; bleeding; coagulopathy HBOC; blood substitute; resuscitation; bleeding; coagulopathy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Roghani, K.; Holtby, R.J.; Jahr, J.S. Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation. J. Funct. Biomater. 2014, 5, 288-295.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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