Next Article in Journal
Caffeic Acid-PLGA Conjugate to Design Protein Drug Delivery Systems Stable to Irradiation
Previous Article in Journal
Electrokinetic and Hemostatic Profiles of Nonwoven Cellulosic/Synthetic Fiber Blends with Unbleached Cotton
Previous Article in Special Issue
Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats

Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation

by 1,2, 1,3,† and 1,*,†
Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine at UCLA, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 3325, Los Angeles, CA 90095, USA
Department of Biology, College of Arts and Sciences, Syracuse University, Syracuse, NY 13244, USA
School of Medicine, St. George's University, Grenada, West Indies
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Funct. Biomater. 2014, 5(4), 288-295;
Received: 24 August 2014 / Revised: 19 November 2014 / Accepted: 25 November 2014 / Published: 12 December 2014
(This article belongs to the Special Issue Blood Substitutes)
For many decades, Hemoglobin-based oxygen carriers (HBOCs) have been central in the development of resuscitation agents that might provide oxygen delivery in addition to simple volume expansion. Since 80% of the world population lives in areas where fresh blood products are not available, the application of these new solutions may prove to be highly beneficial (Kim and Greenburg 2006). Many improvements have been made to earlier generation HBOCs, but various concerns still remain, including coagulopathy, nitric oxide scavenging, platelet interference and decreased calcium concentration secondary to volume expansion (Jahr et al. 2013). This review will summarize the current challenges faced in developing HBOCs that may be used clinically, in order to guide future research efforts in the field. View Full-Text
Keywords: HBOC; blood substitute; resuscitation; bleeding; coagulopathy HBOC; blood substitute; resuscitation; bleeding; coagulopathy
MDPI and ACS Style

Roghani, K.; Holtby, R.J.; Jahr, J.S. Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation. J. Funct. Biomater. 2014, 5, 288-295.

AMA Style

Roghani K, Holtby RJ, Jahr JS. Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation. Journal of Functional Biomaterials. 2014; 5(4):288-295.

Chicago/Turabian Style

Roghani, Kimia, Randall J. Holtby, and Jonathan S. Jahr 2014. "Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation" Journal of Functional Biomaterials 5, no. 4: 288-295.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop