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Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats

1
NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA
2
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20895, USA
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Author to whom correspondence should be addressed.
J. Funct. Biomater. 2014, 5(4), 246-258; https://doi.org/10.3390/jfb5040246
Received: 17 September 2014 / Revised: 7 November 2014 / Accepted: 12 November 2014 / Published: 18 November 2014
(This article belongs to the Special Issue Blood Substitutes)
The use of hemoglobin-based oxygen carriers (HBOC) as oxygen delivering therapies during hypoxic states has been hindered by vasoconstrictive side effects caused by depletion of nitric oxide (NO). OxyVita C is a promising oxygen-carrying solution that consists of a zero-linked hemoglobin polymer with a high molecular weight (~17 MDa). The large molecular weight is believed to prevent extravasation and limit NO scavenging and vasoconstriction. The aim of this study was to assess vasoactive effects of OxyVita C on systemic blood pressures and cerebral pial arteriole diameters. Anesthetized healthy rats received four intravenous (IV) infusions of an increasing dose of OxyVita C (2, 25, 50, 100 mg/kg) and hemodynamic parameters and pial arteriolar diameters were measured pre- and post-infusion. Normal saline was used as a volume-matched control. Systemic blood pressures increased (P ≤ 0.05) with increasing doses of OxyVita C, but not with saline. There was no vasoconstriction in small (<50 µm) and medium-sized (50–100 µm) pial arterioles in the OxyVita C group. In contrast, small and medium-sized pial arterioles vasoconstricted in the control group. Compared to saline, OxyVita C showed no cerebral vasoconstriction after any of the four doses evaluated in this rat model despite increases in blood pressure. View Full-Text
Keywords: cerebral microcirculation; hemoglobin-based oxygen carriers (HBOC); oxygen therapeutic; vasoconstriction; intravital microscopy cerebral microcirculation; hemoglobin-based oxygen carriers (HBOC); oxygen therapeutic; vasoconstriction; intravital microscopy
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Abutarboush, R.; Aligbe, C.; Pappas, G.; Saha, B.; Arnaud, F.; Haque, A.; Auker, C.; McCarron, R.; Scultetus, A.; Moon-Massat, P. Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats. J. Funct. Biomater. 2014, 5, 246-258.

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