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Article

Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota

by
Yuhang Luo
1,
Shujiang Peng
1,
Jintao Cheng
2,
Hongli Yang
1,
Lin Lin
1,
Guiling Yang
2,
Yuanxiang Jin
2,3,
Qingchi Wang
2,* and
Zhengshun Wen
1,2,*
1
School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China
2
Xianghu Laboratory, Hangzhou 311231, China
3
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2024, 15(8), 236; https://doi.org/10.3390/jfb15080236
Submission received: 27 July 2024 / Revised: 16 August 2024 / Accepted: 19 August 2024 / Published: 22 August 2024
(This article belongs to the Special Issue Nanostructured Materials/Biomaterials for Healthcare Applications)
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Abstract

Low molecular weight chitosan selenium nanoparticles (LCS-SeNPs), a biologically active compound derived from selenium polysaccharides, have demonstrated potential in addressing obesity. However, the mechanism through which LCS-SeNPs alleviate high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) remains unclear. Our results elucidated that LCS-SeNPs significantly inhibited fat accumulation and markedly improved the intestinal barrier by increasing mucus secretion from goblet cells. Moreover, LCS-SeNPs reshaped intestinal flora composition by increasing the abundance of mucus-associated microbiota (Bifidobacterium, Akkermansia, and Muribaculaceae_unclassified) and decreasing the abundance of obesity-contributed bacterium (Anaerotruncus, Lachnoclostridium, and Proteus). The modulation of intestinal microbiota by LCS-SeNPs influenced several metabolic pathways, including bile acid secretion, purine metabolites, and tryptophan derivation. Meanwhile, glycocholic acid and tauro-beta-muricholic acid were significantly reduced in the LCS-SeNP group. Our study suggests the crucial role of intestinal microbiota composition and metabolism, providing a new theoretical foundation for utilizing selenium polysaccharides in the intervention of HFD-induced NAFLD.
Keywords: low molecular weight chitosan selenium nanoparticles; intestinal barrier function; non-alcoholic fatty liver disease; intestinal microbiota; metabolomics low molecular weight chitosan selenium nanoparticles; intestinal barrier function; non-alcoholic fatty liver disease; intestinal microbiota; metabolomics

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MDPI and ACS Style

Luo, Y.; Peng, S.; Cheng, J.; Yang, H.; Lin, L.; Yang, G.; Jin, Y.; Wang, Q.; Wen, Z. Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota. J. Funct. Biomater. 2024, 15, 236. https://doi.org/10.3390/jfb15080236

AMA Style

Luo Y, Peng S, Cheng J, Yang H, Lin L, Yang G, Jin Y, Wang Q, Wen Z. Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota. Journal of Functional Biomaterials. 2024; 15(8):236. https://doi.org/10.3390/jfb15080236

Chicago/Turabian Style

Luo, Yuhang, Shujiang Peng, Jintao Cheng, Hongli Yang, Lin Lin, Guiling Yang, Yuanxiang Jin, Qingchi Wang, and Zhengshun Wen. 2024. "Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota" Journal of Functional Biomaterials 15, no. 8: 236. https://doi.org/10.3390/jfb15080236

APA Style

Luo, Y., Peng, S., Cheng, J., Yang, H., Lin, L., Yang, G., Jin, Y., Wang, Q., & Wen, Z. (2024). Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota. Journal of Functional Biomaterials, 15(8), 236. https://doi.org/10.3390/jfb15080236

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