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Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials

ADA Science & Research Institute, LLC, Innovative & Technology Research, Frederick, MD 21704, USA
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J. Funct. Biomater. 2020, 11(3), 54; https://doi.org/10.3390/jfb11030054
Received: 29 June 2020 / Revised: 22 July 2020 / Accepted: 23 July 2020 / Published: 1 August 2020
(This article belongs to the Special Issue Bacterial Interactions with Dental and Medical Materials)
An advancement in preventing secondary caries has been the incorporation of quaternary ammonium containing (QAC) compounds into a composite resin mixture. The permanent positive charge on the monomers allows for electrostatic-based killing of bacteria. Spontaneous adsorption of salivary proteins onto restorations dampens the antimicrobial capabilities of QAC compounds. Protein-repellent monomers can work with QAC restorations to achieve the technology’s full potential. We discuss the theory behind macromolecular adsorption, direct and indirect characterization methods, and advances of protein repellent dental materials. The translation of protein adsorption to microbial colonization is covered, and the concerns and fallbacks of the state-of-the-art protein-resistant monomers are addressed. Last, we present new and exciting avenues for protein repellent monomer design that have yet to be explored in dental materials. View Full-Text
Keywords: protein repellent; restorations; zwitterionic polymers; dental materials; antimicrobial; antifouling protein repellent; restorations; zwitterionic polymers; dental materials; antimicrobial; antifouling
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MDPI and ACS Style

Torres Jr, L.; Bienek, D.R. Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials. J. Funct. Biomater. 2020, 11, 54. https://doi.org/10.3390/jfb11030054

AMA Style

Torres Jr L, Bienek DR. Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials. Journal of Functional Biomaterials. 2020; 11(3):54. https://doi.org/10.3390/jfb11030054

Chicago/Turabian Style

Torres Jr, Leopoldo; Bienek, Diane R. 2020. "Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials" J. Funct. Biomater. 11, no. 3: 54. https://doi.org/10.3390/jfb11030054

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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