Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials
ADA Science & Research Institute, LLC, Innovative & Technology Research, Frederick, MD 21704, USA
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J. Funct. Biomater. 2020, 11(3), 54; https://doi.org/10.3390/jfb11030054
Received: 29 June 2020 / Revised: 22 July 2020 / Accepted: 23 July 2020 / Published: 1 August 2020
(This article belongs to the Special Issue Bacterial Interactions with Dental and Medical Materials)
An advancement in preventing secondary caries has been the incorporation of quaternary ammonium containing (QAC) compounds into a composite resin mixture. The permanent positive charge on the monomers allows for electrostatic-based killing of bacteria. Spontaneous adsorption of salivary proteins onto restorations dampens the antimicrobial capabilities of QAC compounds. Protein-repellent monomers can work with QAC restorations to achieve the technology’s full potential. We discuss the theory behind macromolecular adsorption, direct and indirect characterization methods, and advances of protein repellent dental materials. The translation of protein adsorption to microbial colonization is covered, and the concerns and fallbacks of the state-of-the-art protein-resistant monomers are addressed. Last, we present new and exciting avenues for protein repellent monomer design that have yet to be explored in dental materials.
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Keywords:
protein repellent; restorations; zwitterionic polymers; dental materials; antimicrobial; antifouling
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Torres Jr, L.; Bienek, D.R. Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials. J. Funct. Biomater. 2020, 11, 54. https://doi.org/10.3390/jfb11030054
AMA Style
Torres Jr L, Bienek DR. Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials. Journal of Functional Biomaterials. 2020; 11(3):54. https://doi.org/10.3390/jfb11030054
Chicago/Turabian StyleTorres Jr, Leopoldo; Bienek, Diane R. 2020. "Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials" J. Funct. Biomater. 11, no. 3: 54. https://doi.org/10.3390/jfb11030054
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