Next Article in Journal
Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread
Previous Article in Journal
Design of Silk-Elastin-Like Protein Nanoparticle Systems with Mucoadhesive Properties
Open AccessCommunication

In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

1
Department of Chemistry, Lancaster University, Lancaster LA1 4YB, UK
2
Department of Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YG, UK
3
Politecnico di Torino, Department of Applied Science and Technology, Corso Duca Degli Abruzzi 24, 10129 Turin, Italy
4
Lancashire Teaching Hospitals NHS Trust, Emergency Department, Royal Preston Hospital, Sharoe Green Lane PR2 9HT, UK
5
Advanced Medical Solutions Group PLC., Premier Park, 33 Road One, Winsford Industrial Estate, Winsford, Cheshire CW7 3RT, UK
6
Materials Science Institute, Lancaster University, Lancaster LA1 4YB, UK
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2019, 10(4), 50; https://doi.org/10.3390/jfb10040050
Received: 10 August 2019 / Revised: 8 November 2019 / Accepted: 12 November 2019 / Published: 14 November 2019
In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing. View Full-Text
Keywords: in situ forming; injectable; hydrogel; polysaccharide; bionanocomposite; wound healing in situ forming; injectable; hydrogel; polysaccharide; bionanocomposite; wound healing
Show Figures

Graphical abstract

MDPI and ACS Style

Leone, F.; Firlak, M.; Challen, K.; Bonnefin, W.; Onida, B.; Wright, K.L.; Hardy, J.G. In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications. J. Funct. Biomater. 2019, 10, 50.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop