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Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass

1
Dental Physical Sciences Unit, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UK
2
Department of Mechanical Engineering, College of Engineering, UAEU Al Ain, 15551, UAE
3
Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, 17666, UAE
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2019, 10(1), 15; https://doi.org/10.3390/jfb10010015
Received: 24 August 2018 / Revised: 10 January 2019 / Accepted: 31 January 2019 / Published: 4 March 2019
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Abstract

Porous composite scaffold using an alginate and bioactive glass ICIE16M was synthesized by a simple freeze-drying technique. The scaffold was characterized using compression testing, Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD), X-ray microtomography (XMT) and scanning electron microscopy (SEM). The bioactivity of the scaffold was evaluated by its ability to form apatite on its surface in simulated body fluid (SBF). The data collected showed evidence that the novel material produced had an appropriate pore size for osteoconduction, with an average pore size of 110 µm and maximum pore size of 309 µm. Statistical analysis confirmed that the glass filler significantly (P < 0.05) increased the collapse yield of the scaffolds compared with pure alginate scaffolds. The ICIE16M glass had an amorphous structure, favorable for bioactivity. View Full-Text
Keywords: bone scaffolds; alginate; bioactive glass; freeze-drying; porous; strontium bone scaffolds; alginate; bioactive glass; freeze-drying; porous; strontium
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Hatton, J.; Davis, G.R.; Mourad, A.-H.; Cherupurakal, N.; Hill, R.G.; Mohsin, S. Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass. J. Funct. Biomater. 2019, 10, 15.

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