A Two-Year Follow-Up Cohort Study—Improved Clinical Control over CVD Risk Factors through Weight Loss in Middle-Aged and Older Adults
Abstract
:1. Introduction
2. Material and Methods
2.1. Data Verification
2.2. Anthropometric Measurements
2.3. Laboratory Measurements
2.4. Definitions of Outcome Variables
2.5. The Individual Health Status Questionnaire
2.6. Statistical Analyses
2.7. Sensitivity Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Variables | Total | Stable | Gained | Lost | Lost | Lost | p |
---|---|---|---|---|---|---|---|
at Baseline | >3% and <3% | ≤3% | ≥3% and <5% | ≥5% and <10% | ≥10% | ||
n (%) | 3388 (100) | 1975 (58.3) | 784 (23.1) | 310 (9.1) | 272 (8.0) | 47 (1.4) | <0.001 |
Sex/men, n (%) | 1283 (37.9) | 800 (40.5) | 267 (34.1) | 109 (35.2) | 98 (36.0) | 9 (19.2) | <0.001 |
Age (years) | 55.7 (43.0–64.0) | 55.8 (43.0–64.0) | 55.0 (43.0–64.0) | 56.6 (43.0–64.0) | 55.9 (43.0–64.0) | 55.6 (45.0–64.0) | <0.001 |
Height (cm) | 164.8 (141.0–198.0) | 165.2 (141.0–198.0) | 164.6 (145.0–189.5) | 164.3 (145.0–190.0) | 164.3 (148.0–196.0) | 161.5 (148.0–184.0) | <0.01 |
Weight (kg) | 80.6 (53.2–138.0) | 80.9 (53.2–138.0) | 79.7 (57.4–135.4) | 80.1 (57.8–123.8) | 81.3 (55.7–120.8) | 81.5 (61.5–120.5) | >0.05 |
BF (%) | 34.6 (12.9–57.4) | 34.4 (12.9–57.4) | 34.6 (14.1–53.7) | 35.1 (18.9–53.7) | 35.1 (19.3–50.5) | 38.6 (20.4–47.8) | <0.001 |
BMI (kg/m2) | 29.6 (25.0–52.3) | 29.6 (25.0–52.3) | 29.4 (25.0–47.2) | 29.6 (25.0–46.6) | 30.0 (25.0–47.8) | 31.2 (25.0–41.5) | <0.01 |
WC (cm) | 95.2 (64.0–142) | 95.5 (68.0–135.0) | 94.2 (70.0–142) | 95.0 (71.0–140.0) | 95.7 (73.0–133.0) | 96.3 (64.0–118.0) | <0.05 |
WHR | 0.9 (0.6–1.7) | 0.9 (0.6–1.7) | 0.9 (0.7–1.2) | 0.9 (0.7–1.2) | 0.9 (0.7–1.2) | 0.9 (0.7–1.0) | <0.05 |
WHTR | 0.6 (0.4–0.9) | 0.6 (0.4–0.8) | 0.6 (0.5–0.8) | 0.6 (0.4–0.9) | 0.6 (0.5–0.8) | 0.6 (0.4–0.8) | <0.01 |
SBP (mm/Hg) | 139.5 (92.5–230.0) | 140 (92.5–230.0) | 137.6 (93.5–207.0) | 138.6 (103.5–203.5) | 141.7 (98.0–214.0) | 144.3 (96.5–224.0) | <0.01 |
DBP (mm/Hg) | 82.5 (50.0–136.5) | 82.9 (50.0–136.5) | 81.5 (57.5–123.0) | 81.8 (54.5–133.0) | 83.2 (56.5–114.5) | 82.3 (58.5–106.0) | <0.01 |
FBG (mg/dL) | 99.5 (66.1–358.0) | 99.5 (70.0–358.0) | 98.1 (66.1–256.0) | 98.9 (72.0–219.0) | 102.5 (68.0–310.0) | 107.7 (75.0–238.0) | <0.05 |
HDL-C (mg/dL) | 56.5 (20.0–134.0) | 56.1 (20.2–120.0) | 57.6 (27.0–134.0) | 55.7 (20.0–98.0) | 56.6 (27.2–104.0) | 60.8 (28.0–100.0) | <0.05 |
LDL-C (mg/dL) | 127.1 (35.4–277.4) | 128.0 (41.2–277.4) | 124.2 (35.4–252.2) | 130.5 (52.6–211.6) | 125.6 (39.8–260.8) | 122.9 (64.7–179.2) | >0.05 |
TC (mg/dL) | 208.1 (98.0–361.0) | 209.1 (100.0–360.0) | 204.8 (98.0–353.0) | 210.4 (103.0–316.0) | 206.6 (110.0–361.0) | 209.9 (142.9–290.0) | >0.05 |
TG (mg/dL) | 122.2 (28.0–397.0) | 125.2 (28.0–389.0) | 114.5 (36.0–353.0) | 121.3 (37.0–397.0) | 122.1 (34.0–371.0) | 130.6 (52.0–338.0) | <0.001 |
BMI ≥ 30, n (%) | 1248 (36.8) | 732 (37.1) | 270 (34.4) | 113 (36.5) | 109 (40.1) | 24 (51.1) | >0.5 |
Smoker, n (%) | 483 (14.3) | 267 (13.5) | 137 (17.5) | 44 (14.2) | 29 (10.7) | 6 (12.8) | <0.05 |
Drinker, n (%) | 2912 (86.0) | 1714 (86.8) | 667 (85.1) | 266 (85.8) | 227 (83.5) | 38 (80.9) | >0.05 |
MVPA, n (%) | 1062 (31.4) | 653 (33.1) | 234 (29.9) | 94 (30.3) | 73 (26.8) | 8 (17.0) | <0.05 |
Variables | Total at Baseline | Stable | Gained | Lost | Lost | Lost |
---|---|---|---|---|---|---|
>−3% and <3% | ≥3% | ≥3% and <5% | ≥5% and <10% | ≥10% | ||
n (%) | 3388 (100) | 1975 (58.3) | 784 (23.1) | 310 (9.1) | 272 (8.0) | 47 (1.4) |
SBP (mm/Hg) | 139.5 ± 18.9 | −4.9 ± 16.0 | −2.1 ± 16.2 *** | −6.9 ± 16.0 | −9.7 ± 16.3 *** | −9.5 ± 17.3 |
DBP (mm/Hg) | 82.5 ± 10.2 | 1.5 ± 9.1 | 0.4 ± 9.4 *** | −2.5 ± 10.3 | −3.8 ± 9.4 *** | −3.1 ± 10.0 |
FBG (mg/dL) | 99.5 ± 19.4 | −0.4 ± 16.3 | 1.5 ± 14.0 ** | −1.1 ± 16.8 | −4.4 ± 18.7 *** | −9.4 ± 25.1 ** |
HDL-C (mg/dL) | 56.5 ± 13.7 | −4.7 ± 8.8 | −6.1 ± 9.5 ** | −4.2 ± 8.0 | −2.8 ± 10.4 ** | −2.3 ± 11.4 |
LDL-C (mg/dL) | 127.1 ± 33.6 | −6.7 ± 31.7 | −3.4 ± 30.5 ** | −8.6 ± 29.0 | −6.3 ± 31.0 | −2.5 ± 29.3 |
TG (mg/dL) | 122.2 ± 58.1 | 7.9 ± 54.4 | 21.5 ± 52.0 *** | −1.4 ± 47.1 *** | −5.3 ± 55.5 *** | −30.9 ± 58.8 *** |
Variables | Gained ≥3% | Stable >−3% and <3% | Lost ≥3 to <5% | Lost ≥5 to <10% | Lost ≥10% |
---|---|---|---|---|---|
SBP 5 mm/Hg decrease | 0.81 (0.70, 0.93) * | 1 (ref) | 0.99 (0.83, 1.18) | 1.40 (1.22, 1.60) ** | 1.15 (0.74, 1.77) |
DBP 5 mm/Hg decrease | 0.74 (0.60, 0.90) * | 1 (ref) | 1.21 (0.97, 1.51) | 1.45 (1.18, 1.78) * | 1.27 (0.72, 2.24) |
FBG 20 mg/dL decrease | 1.60 (0.82, 3.10) | 1 (ref) | 2.19 (0.99, 4.83) | 3.34 (1.64, 6.79) ** | 2.58 (0.34, 19.71) |
HDL-C 5 mg/dL increase | 0.80 (0.56, 1.15) | 1 (ref) | 1.11 (0.70, 1.78) | 1.99 (1.37, 2.91) ** | 2.11 (0.89, 5.01) |
LDL-C 10 mg/dL decrease | 0.80 (0.67, 0.95) * | 1 (ref) | 1.07 (0.88, 1.31) | 1.04 (0.83, 1.29) | 1.29 (0.80, 2.10) |
TGC 40 mg/dL decrease | 0.73 (0.50, 1.06) | 1 (ref) | 1.56 (1.08, 2.25) * | 1.80 (1.23, 2.64) ** | 2.11 (0.85, 5.25) |
Absolute | Total | Stable | Gained | Lost | Lost | Lost | p |
---|---|---|---|---|---|---|---|
Risk | >−3% and <3% | ≥3% | ≥3% and <5% | ≥5% and <10% | ≥10% | ||
Baseline | <0.001 | ||||||
Low | 223 (8.3) | 127 (8.2) | 66 (10.4) | 14 (5.8) | 14 (6.6) | 2 (5.9) | |
Moderate | 1859 (69.6) | 1035 (66.9) | 454 (71.4) | 176 (72.4) | 165 (78.2) | 29 (85.3) | |
High to very high | 589 (22.1) | 385 (24.9) | 116 (18.2) | 53 (21.8) | 32 (15.2) | 3 (8.8) | |
Follow-up | <0.001 | ||||||
Low | 226 (8.5) | 127 (8.2) | 71 (11.2) | 13 (5.4) | 13 (6.2) | 2 (5.9) | |
Moderate | 1949 (73.0) ** | 1101 (71.2) ** | 458 (72.0) | 186 (76.5) | 174 (82.5) | 30 (88.2) | |
High to very high | 496 (18.6) ** | 319 (20.6) ** | 107 (16.8) * | 44 (18.1) | 24 (11.4) | 2 (5.9) |
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Macek, P.; Terek-Derszniak, M.; Biskup, M.; Krol, H.; Smok-Kalwat, J.; Gozdz, S.; Zak, M. A Two-Year Follow-Up Cohort Study—Improved Clinical Control over CVD Risk Factors through Weight Loss in Middle-Aged and Older Adults. J. Clin. Med. 2020, 9, 2904. https://doi.org/10.3390/jcm9092904
Macek P, Terek-Derszniak M, Biskup M, Krol H, Smok-Kalwat J, Gozdz S, Zak M. A Two-Year Follow-Up Cohort Study—Improved Clinical Control over CVD Risk Factors through Weight Loss in Middle-Aged and Older Adults. Journal of Clinical Medicine. 2020; 9(9):2904. https://doi.org/10.3390/jcm9092904
Chicago/Turabian StyleMacek, Pawel, Malgorzata Terek-Derszniak, Malgorzata Biskup, Halina Krol, Jolanta Smok-Kalwat, Stanislaw Gozdz, and Marek Zak. 2020. "A Two-Year Follow-Up Cohort Study—Improved Clinical Control over CVD Risk Factors through Weight Loss in Middle-Aged and Older Adults" Journal of Clinical Medicine 9, no. 9: 2904. https://doi.org/10.3390/jcm9092904