Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study
Abstract
:1. Introduction
2. Methods
2.1. Study Design
2.2. Study Population and Inclusion-Exclusion Criteria
2.3. Assessment of Patient-Centred Health Outcomes in Quality of Life
2.4. Statistical Analysis
3. Results
4. Discussion
Limitations of the Study
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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n | Overall n = 1028 | Women n = 309 (30%) | Men n = 719 (70%) | p Value | |
---|---|---|---|---|---|
Age (years) | 1015 | 71 ± 11 | 73 ± 10 | 70 ± 11 | <0.0001 |
BMI (kg/m2) | 997 | 27.7 ± 3,9 | 28.2 ± 4,4 | 27.5 ± 3.6 | 0.010 |
Systolic Blood Pressure (mmHg) | 1022 | 127 ± 19 | 129 ± 20 | 126 ± 18 | 0.092 |
Heart rate (bpm) | 1021 | 74 ± 16 | 76 ± 16 | 73 ± 15 | 0.017 |
NYHA Functional class I-II vs. III-IV | 994 | 546 (54.9)/448 (45.1) | 158 (53.4)/138 (54.6) | 388(55.6)/310 (44.4) | 0.531 |
Previous HF admission, | 1028 | 860 (83.7) | 262 (84.8) | 598 (83.2) | 0.581 |
HF admission <6 months, | 1028 | 507 (49.3) | 148 (47.9) | 359 (49.9) | 0.586 |
Time from diagnosis (years) | 936 | 2.7 (0.9–5.9) | 2.8 (0.9–6.3) | 2.7 (0.9–5.7) | 0.690 |
LVEF (%) | 993 | 33.7 ± 6.8 | 34.4 ± 6.7 | 33.4 ± 6.8 | 0.027 |
Ischemic etiology of HF | 1028 | 521 (50.7) | 100 (32.4) | 421 (58.6) | <0.0001 |
Comorbidities | |||||
Hypertension | 1028 | 815 (79.3) | 240 (77.7) | 575 (80.0) | 0.403 |
Diabetes mellitus | 1028 | 450 (43.8) | 141 (45.6) | 309 (43.0) | 0.451 |
Previous AMI | 1028 | 447 (43.5) | 91 (29.4) | 356 (49.5) | <0.0001 |
Dislipidemia | 1028 | 704 (68.5) | 196 (63.4) | 508 (70.7) | 0.023 |
Chronic kidney disease | 1028 | 242 (23.5) | 63 (20.4) | 179 (24.9) | 0.128 |
Atrial Fibrillation | 1028 | 443 (45.5) | 150 (51.5) | 293 (43.0) | 0.017 |
Anemia | 1028 | 194 (18.9) | 80 (25.9) | 114 (15.9) | 0.0003 |
COPD | 1028 | 199 (19.4) | 28 (9.1) | 171 (23.8) | <0.0001 |
TIA/Stroke | 1028 | 142 (13.8) | 47 (15.2) | 95 (13.2) | 0.430 |
Anemia | 1028 | 204 (19.8) | 44 (14.2) | 160 (22.3) | 0.003 |
Cancer | 1028 | 81 (7.9) | 30 (9.7) | 51 (7.1) | 0.165 |
Chronic Hepatopathy | 1028 | 43 (4.2) | 7 (2.3) | 36 (5.0) | 0.060 |
Obesity | 1028 | 239 (23.2) | 98 (31.7) | 141 (19.6) | <0.0001 |
Low weight | 1028 | 13 (1.3) | 6 (1.9) | 7 (1.0) | 0.227 |
Overweight | 1028 | 801 (77.9) | 239 (77.3) | 562 (78.2) | 0.806 |
Sleep Apnea | 1028 | 94 (9.1) | 13 (4.2) | 81 (11.3) | 0.0002 |
Comorbidities (n) | 1028 | 3.5 ± 1.9 | 3.2 ± 1.8 | 3.7 ± 1.9 | 0.0002 |
Charlson index (points) | 527 | 4.4 ± 2.8 | 3.98 ± 2.4 | 4.6 ± 3.0 | 0.009 |
Medications | |||||
ACEIs or ARBs | 1028 | 922 (89.7) | 274 (88.7) | 648 (90.1) | 0.503 |
Beta-blockers | 1028 | 787 (76.6) | 224 (72.5) | 563 (78.3) | 0.045 |
MRAs | 1028 | 684 (66.5) | 202 (65.4) | 482 (67.0) | 0.614 |
Ivabradine | 1028 | 91 (8.9) | 21 (6.8) | 70 (9.7) | 0.151 |
Digoxin | 1028 | 221 (21.5) | 82 (26.5) | 139 (19.3) | 0.013 |
Diuretics | 1028 | 917 (89.2) | 281 (90.9) | 636 (88.5) | 0.273 |
Statins | 1028 | 779 (75.8) | 214 (69.3) | 565 (78.6) | 0.002 |
Antiplatelets | 1028 | 618 (60.1) | 154 (49.8) | 464 (64.5) | <0.0001 |
Anticoagulants | 1028 | 410 (39.9) | 143 (46.3) | 267 (37.1) | 0.007 |
Laboratory parameters | |||||
Hemoglobin (g/dL) | 971 | 12.9 ± 1.7 | 12.4 ± 1.4 | 13.1 ± 1.7 | <0.0001 |
eGFR (mL/min/1.73 m2) | 573 | 60.0 (45.0–70.0) | 60.0 (45.0–70.5) | 60.0 (45.0–70.0) | 0.542 |
Creatinine clearance <60 mL/min | 573 | 259 (45.2) | 85 (48.9) | 174 (43.6) | 0.274 |
NT-proBNP (pg/mL) | 238 | 1345 (504–2390) | 1348 (422–2333) | 1333 (537–2411) | 0.600 |
BNP (pg/mL) | 154 | 216 (124–430) | 211 (125–397) | 232 (124–453) | 0.258 |
n | Overall n = 1028 | Women n = 309 | Men n = 719 | p Value | |
---|---|---|---|---|---|
KCCQ Subdomain Score | |||||
Physical Limitation | 1023 | 61.1 ± 28.0 | 53.3 ± 29.1 | 64.5 ± 26.9 | <0.0001 |
Symptom Stability | 1022 | 59.5 ± 23.2 | 59.2 ± 24.0 | 59.7 ± 22.9 | 0.761 |
Symptom Frequency | 1027 | 66.4 ± 26.0 | 60.8 ± 26.7 | 68.7 ± 25.4 | <0.0001 |
Symptom Burden | 1027 | 67.2 ± 26.0 | 61.6 ± 26.5 | 69.6 ± 25.5 | <0.0001 |
Self-Efficacy | 1026 | 69.1 ± 22.5 | 67.9 ± 22.8 | 69.6 ± 22.3 | 0.262 |
Quality of Life | 1026 | 54.4 ± 24.1 | 50.8 ± 24.0 | 55.9 ± 24.0 | 0.002 |
Social Limitation | 1018 | 61.6 ± 29.4 | 55.8 ± 29.5 | 64.1 ± 29.0 | <0.0001 |
KCCQ, Summary Scores | |||||
Overall Summary Score | 1014 | 60.9 ± 24.5 | 55.0 ± 24.6 | 63.4 ± 24.0 | <0.0001 |
Clinical Summary Score | 1023 | 63.9 ± 25.1 | 57.3 ± 25.7 | 66.8 ± 24.4 | <0.0001 |
Total Symptom Score | 1027 | 66.8 ± 25.4 | 61.2 ± 25.9 | 69.2 ± 25.5 | <0.0001 |
EQ 5D, % patients reporting issues | |||||
Mobility | 1001 | 581 (58.0) | 212 (69.3) | 369 (53.1) | <0.0001 |
Self-Care | 1001 | 581 (58.0) | 212 (69.3) | 369 (53.1) | <0.0001 |
Usual Activities | 1000 | 615 (61.5) | 217 (70.9) | 398 (57.3) | <0.0001 |
Pain/Discomfort | 999 | 506 (50.7) | 192 (62.7) | 314 (45.3) | <0.0001 |
Anxiety/Depression | 999 | 490 (59.0) | 166 (54.2) | 324 (46.8) | 0.033 |
EQ 5D Summary Scores | |||||
EQ 5D Index | 993 | 0.65 ± 0.26 | 0.58 ± 0.26 | 0.67 ± 0.25 | <0.0001 |
Visual analogue scale | 1013 | 60.8 ± 20.0 | 57.5 ± 20.8 | 62.2 ± 19.4 | 0.001 |
Women | Men | p Value | |
---|---|---|---|
LVEF >30% | 56.0 ± 1.5 | 63.3 ± 1.0 | <0.001 |
LVEF <30% | 52.8 ± 2.1 | 61.3 ± 1.4 | 0.003 |
p value for interaction | 0.669 * | ||
Age <75 years | 56.1 ± 1.8 | 64.2 ± 1.0 | <0.001 |
Age >75 years | 53.0 ± 1.7 | 60.3 ± 1.3 | 0.001 |
p value for interaction | 0.766 * | ||
NYHA I-II | 66.2 ± 1.8 | 72.7 ± 1.1 | 0.003 |
NYHA III-IV | 42.1 ± 1.8 | 51.2 ± 1.2 | <0.001 |
p value for interaction | 0.364 * | ||
Comorbidities number <5 | 54.9 ± 1.8 | 64.4 ± 1.3 | <0.001 |
Comorbidities number >5 | 55.3 ± 2.0 | 61.0 ± 1.2 | 0.005 |
p value for interaction | 0.193 * | ||
Ischemic etiology: yes | 55.3 ± 1.5 | 62.9 ± 1.3 | <0.001 |
Ischemic etiology: no | 54.5 ± 2.1 | 62.3 ± 1.0 | <0.001 |
p value for interaction | 0.959 * | ||
Recent admission: yes | 58.3 ± 1.8 | 66.2 ± 1.1 | <0.001 |
Recent admission: no | 51.4 ± 1.7 | 59.0 ± 1.2 | <0.001 |
p value for interaction | 0.902 * |
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Garay, A.; Tapia, J.; Anguita, M.; Formiga, F.; Almenar, L.; Crespo-Leiro, M.G.; Manzano, L.; Muñiz, J.; Chaves, J.; De Frutos, T.; et al. Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study. J. Clin. Med. 2020, 9, 2825. https://doi.org/10.3390/jcm9092825
Garay A, Tapia J, Anguita M, Formiga F, Almenar L, Crespo-Leiro MG, Manzano L, Muñiz J, Chaves J, De Frutos T, et al. Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study. Journal of Clinical Medicine. 2020; 9(9):2825. https://doi.org/10.3390/jcm9092825
Chicago/Turabian StyleGaray, Alberto, Javier Tapia, Manuel Anguita, Francesc Formiga, Luis Almenar, María G. Crespo-Leiro, Luis Manzano, Javier Muñiz, José Chaves, Trinidad De Frutos, and et al. 2020. "Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study" Journal of Clinical Medicine 9, no. 9: 2825. https://doi.org/10.3390/jcm9092825