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Article

Clinical Applicability of the Specific Risk Score of Dementia in Type 2 Diabetes in the Identification of Patients with Early Cognitive Impairment: Results of the MOPEAD Study in Spain

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Institut de Recerca Vall d’Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), 08035 Barcelona, Spain
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CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, 28029 Madrid, Spain
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Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, 08028 Barcelona, Spain
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GMV Soluciones Globales Internet SAU, 28760 Valencia, Spain
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International Corporate Affairs, Alzheimer’s Disease, Eli Lilly and Co., 50019 Firenze, Italy
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Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(9), 2726; https://doi.org/10.3390/jcm9092726
Received: 21 July 2020 / Revised: 18 August 2020 / Accepted: 19 August 2020 / Published: 24 August 2020
(This article belongs to the Special Issue Pathophysiology and Complications of Type 2 Diabetes Mellitus)
Introduction: Although the Diabetes Specific Dementia Risk Score (DSDRS) was proposed for predicting risk of dementia at 10 years, its usefulness as a screening tool is unknown. For this purpose, the European consortium MOPEAD included the DSDRS within the specific strategy for screening of cognitive impairment in type 2 diabetes (T2D) patients attended in a third-level hospital. Material and Methods: T2D patients > 65 years, without known cognitive impairment, attended in a third-level hospital, were evaluated. As per MOPEAD protocol, patients with MMSE ≤ 27 or DSDRS ≥ 7 were referred to the memory clinic for complete neuropsychological assessment. Results: 112 T2D patients were recruited. A total of 82 fulfilled the criteria for referral to the memory unit (43 of them declined referral: 48.8% for associated comorbidities, 37.2% lack of interest, 13.95% lack of social support). At the Fundació ACE’s Memory Clinic, 34 cases (87.2%) of mild cognitive impairment (MCI) and 3 cases (7.7%) of dementia were diagnosed. The predictive value of DSDRS ≥ 7 as a screening tool of cognitive impairment was AUROC = 0.739, p 0.024, CI 95% (0.609–0.825). Conclusions: We found a high prevalence of unknown cognitive impairment in TD2 patients who attended a third-level hospital. The DSDRS was found to be a useful screening tool. The presence of associated comorbidities was the main factor of declining referral. View Full-Text
Keywords: type 2 diabetes; mild cognitive impairment; Alzheimer’s disease type 2 diabetes; mild cognitive impairment; Alzheimer’s disease
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MDPI and ACS Style

Ortiz Zuñiga, A.M.; Simó, R.; Rodriguez-Gómez, O.; Hernández, C.; Rodrigo, A.; Jamilis, L.; Campo, L.; Alegret, M.; Boada, M.; Ciudin, A. Clinical Applicability of the Specific Risk Score of Dementia in Type 2 Diabetes in the Identification of Patients with Early Cognitive Impairment: Results of the MOPEAD Study in Spain. J. Clin. Med. 2020, 9, 2726. https://doi.org/10.3390/jcm9092726

AMA Style

Ortiz Zuñiga AM, Simó R, Rodriguez-Gómez O, Hernández C, Rodrigo A, Jamilis L, Campo L, Alegret M, Boada M, Ciudin A. Clinical Applicability of the Specific Risk Score of Dementia in Type 2 Diabetes in the Identification of Patients with Early Cognitive Impairment: Results of the MOPEAD Study in Spain. Journal of Clinical Medicine. 2020; 9(9):2726. https://doi.org/10.3390/jcm9092726

Chicago/Turabian Style

Ortiz Zuñiga, Angel M., Rafael Simó, Octavio Rodriguez-Gómez, Cristina Hernández, Adrian Rodrigo, Laura Jamilis, Laura Campo, Montserrat Alegret, Merce Boada, and Andreea Ciudin. 2020. "Clinical Applicability of the Specific Risk Score of Dementia in Type 2 Diabetes in the Identification of Patients with Early Cognitive Impairment: Results of the MOPEAD Study in Spain" Journal of Clinical Medicine 9, no. 9: 2726. https://doi.org/10.3390/jcm9092726

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