Efficacy of Dupilumab on Different Phenotypes of Atopic Dermatitis: One-Year Experience of 221 Patients
Abstract
:1. Introduction
2. Materials and Methods
Statistical Analyses
3. Results
3.1. Overview
3.2. AD Phenotypes
3.2.1. Classic: Lichenified/Exudative Flexural Dermatitis, Almost Always Associated with Head-and-Neck Eczema and/or Hand Eczema (101 Patients)
3.2.2. Generalized Eczema with an Inflammatory Pattern (41 Patients)
3.2.3. Generalized Eczema with a Lichenoid Pattern (42 Patients)
3.2.4. Prurigo (18 Patients)
3.2.5. Nummular Eczema (Eight Patients)
3.2.6. Erythroderma (11 Patients)
3.3. Statistical Analysis for the Different Clinical Phenotypes
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Group | Group | p-Value | 95% Confidence Interval (CI) | |
---|---|---|---|---|
Lower Limit | Upper Limit | |||
1 | 2 | 0.003 | −6.4972 | −1.3437 |
3 | 0.012 | −5.8377 | −0.728 | |
4 | 0.963 | −3.6421 | 3.4732 | |
5 | 0.123 | −9.1203 | 1.0903 | |
6 | 0.000 | −15.5539 | −6.7261 |
Clinical Phenotype | Total Number of Patients (% of 221 Patients) | Number of Patients with Early-Onset AD (% of 161 Patients with Early-Onset AD) | Number of Patients with Adult-Onset AD (% of 60 Patients with Adult-Onset AD) |
---|---|---|---|
Classic: Lichenified/exudative flexural dermatitis, almost always associated with head-and-neck eczema and/or hand eczema | 101 (45.7%) | 74 (45.95%) | 27 (45%) |
Generalized eczema with an inflammatory pattern | 41 (18.55%) | 34 (21.12%) | 7 (11.67%) |
Generalized eczema with a lichenoid pattern | 42 (19%) | 33 (20.5%) | 9 (15%) |
Prurigo | 18 (8.14%) | 5 (3.11%) | 13 (21.67%) |
Nummular eczema | 8 (3.63%) | 5 (3.11%) | 3 (5%) |
Erythroderma | 11 (4.98%) | 10 (6.21%) | 1 (1.66%) |
Total number of patients | 221 | 161 | 60 |
Timepoints | Number of Patients (%) | EASI (% Reduction) | EASI75 | DLQI (% Reduction) |
---|---|---|---|---|
Baseline | 221 | 30.73 | 16.41 | |
4 weeks | 221 (100%) | 8.66 (71.03%) | 49.77% (110 patients) | 7.02 (57.74%) |
16 weeks | 154 (69.68%) | 5.29 (82.4%) | 75.97% (117 patients) | 4.72 (71.46%) |
52 weeks | 72 (32.58%) | 4.59 (84.64%) | 83.33% (60 patients) | 2.8 (83.14%) |
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Tavecchio, S.; Angileri, L.; Pozzo Giuffrida, F.; Germiniasi, F.; Marzano, A.V.; Ferrucci, S. Efficacy of Dupilumab on Different Phenotypes of Atopic Dermatitis: One-Year Experience of 221 Patients. J. Clin. Med. 2020, 9, 2684. https://doi.org/10.3390/jcm9092684
Tavecchio S, Angileri L, Pozzo Giuffrida F, Germiniasi F, Marzano AV, Ferrucci S. Efficacy of Dupilumab on Different Phenotypes of Atopic Dermatitis: One-Year Experience of 221 Patients. Journal of Clinical Medicine. 2020; 9(9):2684. https://doi.org/10.3390/jcm9092684
Chicago/Turabian StyleTavecchio, Simona, Luisa Angileri, Francesco Pozzo Giuffrida, Francesca Germiniasi, Angelo Valerio Marzano, and Silvia Ferrucci. 2020. "Efficacy of Dupilumab on Different Phenotypes of Atopic Dermatitis: One-Year Experience of 221 Patients" Journal of Clinical Medicine 9, no. 9: 2684. https://doi.org/10.3390/jcm9092684