Long-Term Outcome of Epiretinal Membrane Surgery in Patients with Internal Limiting Membrane Dehiscence
Abstract
:1. Introduction
2. Methods
2.1. Patients
2.2. Analyses of ILM Dehiscence and Optical Coherence Tomography (OCT) Measurements
2.3. Statistical Analyses
3. Results
3.1. Demographics
3.2. Changes in Visual Acuity, SFT, and IRLT after Surgery
3.3. Thickness of Each Retinal Layer at 12 Months after Surgery
3.4. Univariate and Multivariate Linear Regression Analyses in Patients with ILM Dehiscence
3.5. Univariate and Multivariate Logistic Regression Analyses for Determining the Factors Associated with ILM Dehiscence
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Group 1 (n = 46) | Group 2 (n = 40) | p-Value | |
---|---|---|---|
Age | 65.5 ± 9.3 | 67.9 ± 9.1 | 0.059 |
Sex (men, %) | 17 (37.0%) | 21 (52.5%) | 0.076 |
Hypertension (n, %) | 17 (37.0%) | 18 (45.0%) | 0.513 |
Diabetes (n, %) | 6 (13.0%) | 8 (20%) | 0.400 |
Laterality (right, %) | 26 (56.5%) | 21 (52.5%) | 0.709 |
Spherical equivalent | −0.34 ± 1.59 | −0.14 ± 1.69 | 0.570 |
BCVA | 0.46 ± 0.29 | 0.45 ± 0.25 | 0.801 |
Intraocular pressure | 14.7 ± 3.0 | 13.8 ± 3.6 | 0.210 |
Axial length | 23.4 ± 1.1 | 23.5 ± 0.9 | 0.704 |
Lens status (phakic, %) | 28 (60.9%) | 28 (70.0%) | 0.497 |
Photoreceptor layer disruption (%) | 24 (52.2%) | 17 (42.5%) | 0.395 |
Stage of ERM | 2.9 ± 0.8 | 2.6 ± 0.8 | 0.116 |
Retinal layer thickness | |||
SFT | 507.4 ± 80.0 | 417.6 ± 63.6 | <0.001 |
IRLT | 270.2 ± 74.3 | 182.6 ± 60.4 | <0.001 |
OPL | 40.2 ± 7.1 | 38.9 ± 9.0 | 0.449 |
ONL | 110.4 ± 24.5 | 104.6 ± 24.2 | 0.274 |
PRL | 72.0 ± 4.8 | 72.1 ± 4.2 | 0.995 |
RPE | 15.6 ± 2.8 | 15.8 ± 3.3 | 0.778 |
Group 1 | Group 2 | ||||||||
---|---|---|---|---|---|---|---|---|---|
BCVA | SFT | IRLT | BCVA | SFT | IRLT | p-Value * | p-Value † | p-Value ‡ | |
Baseline | 0.46 ± 0.29 | 507.4 ± 80.0 | 270.2 ± 74.3 | 0.45 ± 0.25 | 417.6 ± 63.6 | 182.6 ± 60.4 | 0.801 | <0.001 | <0.001 |
1 month | 0.24 ± 0.21 | 438.8 ± 62.9 | 201.1 ± 54.9 | 0.18 ± 0.16 | 387.3 ± 71.8 | 150.7 ± 46.9 | 0.137 | 0.001 | <0.001 |
3 months | 0.23 ± 0.21 | 427.5 ± 56.2 | 173.9 ± 42.1 | 0.14 ± 0.14 | 386.1 ± 69.7 | 141.9 ± 43.2 | 0.019 | 0.003 | 0.001 |
6 months | 0.21 ± 0.22 | 409.4 ± 53.2 | 166.2 ± 40.9 | 0.11 ± 0.12 | 380.5 ± 60.7 | 141.1 ± 44.0 | 0.014 | 0.021 | 0.010 |
12 months | 0.18 ± 0.17 | 400.2 ± 47.1 | 165.4 ± 41.2 | 0.08 ± 0.09 | 364.8 ± 53.7 | 138.1 ± 44.2 | 0.002 | 0.002 | 0.004 |
Group 1 | Group 2 | p-Value | |
---|---|---|---|
SFT | 400.2 ± 47.1 | 364.8 ± 53.7 | 0.002 |
IRLT | 165.4 ± 41.2 | 138.1 ± 44.2 | 0.004 |
RNFL | 28.8 ± 23.6 | 22.7 ± 19.1 | 0.189 |
GCL | 43.5 ± 11.5 | 35.9 ± 15.2 | 0.010 |
IPL | 40.3 ± 10.1 | 35.6 ± 10.2 | 0.003 |
INL | 52.9 ± 12.0 | 46.0 ± 13.9 | 0.016 |
OPL | 36.7 ± 8.8 | 33.2 ± 8.8 | 0.070 |
ONL | 114.9 ± 22.6 | 113.7 ± 21.3 | 0.807 |
PRL | 73.0 ± 4.3 | 72.3 ± 4.3 | 0.498 |
RPE | 17.6 ± 6.5 | 17.2 ± 6.2 | 0.727 |
Univariate | Multivariate | |||
---|---|---|---|---|
B (95% CI) | p-Value | B (95% CI) | p-Value | |
Age | 0.002 (−0.004–0.008) | 0.457 | ||
Sex | 0.054 (−0.060–0.168) | 0.344 | ||
Hypertension | 0.018 (−0.089–0.125) | 0.738 | ||
Diabetes | −0.037 (−0.190–0.116) | 0.628 | ||
Laterality | −0.015 (−0.120–0.089) | 0.767 | ||
SE | −0.017 (−0.050–0.015) | 0.286 | ||
IOP | −0.001 (−0.018–0.017) | 0.922 | ||
Axial length | 0.003 (−0.045–0.050) | 0.902 | ||
Baseline BCVA | 0.174 (0.004–0.344) | 0.045 | 0.109 (−0.082–0.300) | 0.254 |
Baseline SFT | 0.001 (<0.001–0.001) | 0.027 | <0.001 (−0.002–0.001) | 0.353 |
Baseline IRLT | 0.001 (<0.001–0.001) | 0.036 | −0.001 (−0.002–0.000) | 0.555 |
Lens status | 0.063 (−0.0420–0.167) | 0.231 | ||
Tear size | 0.073 (−0.029–0.175) | 0.159 | ||
Tear location | −0.135 (−0.231−0.039) | 0.007 | −0.105 (−0.203−0.008) | 0.034 |
PRL disruption | 0.101 (0.002–0.200) | 0.045 | 0.069 (−0.024–0.162) | 0.144 |
Stage of ERM | 0.051 (−0.009–0.112) | 0.094 | ||
Final SFT | 0.001 (< 0.001–0.002) | 0.020 | <0.001 (−0.002–0.002) | 0.725 |
Final IRLT | 0.002 (0.001–0.003) | 0.009 | 0.001 (0.000–0.002) | 0.046 |
Univariate | Multivariate | |||
---|---|---|---|---|
B (OR) | p-Value | B (95% CI) | p-Value | |
Age | −0.055 (0.947) | 0.027 | −0.051 (0.950) | 0.103 |
Sex | 1.158 (3.184) | 0.100 | ||
Hypertension | 0.448 (1.565) | 0.310 | ||
Diabetes | 0.455 (1.576) | 0.441 | ||
Laterality | 0.265 (1.303) | 0.542 | ||
SE | −0.089 (0.915) | 0.513 | ||
IOP | 0.091 (1.095) | 0.181 | ||
Axial length | −0.092 (0.912) | 0.675 | ||
Baseline BCVA | 0.240 (1.271) | 0.764 | ||
Baseline SFT | 0.019 (1.020) | <0.001 | 0.009 (1.009) | 0.367 |
Baseline IRLT | 0.021 (1.021) | <0.001 | 0.018 (1.018) | <0.001 |
Lens status | 0.268 (1.308) | 0.556 | ||
Photoreceptor layer disruption | 0.478 (1.613) | 0.272 | ||
Stage of ERM | 0.472 (1.603) | 0.080 | ||
Final BCVA | 6.310 (55.190) | 0.004 | 4.431 (83.987) | 0.039 |
Final SFT | 0.015 (1.015) | 0.002 | −0.004 (0.996) | 0.364 |
Final IRLT | 0.018 (1.018) | 0.003 | 0.009 (1.009) | 0.438 |
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Lee, M.-W.; Jung, I.; Song, Y.-Y.; Baek, S.-K.; Lee, Y.-H. Long-Term Outcome of Epiretinal Membrane Surgery in Patients with Internal Limiting Membrane Dehiscence. J. Clin. Med. 2020, 9, 2470. https://doi.org/10.3390/jcm9082470
Lee M-W, Jung I, Song Y-Y, Baek S-K, Lee Y-H. Long-Term Outcome of Epiretinal Membrane Surgery in Patients with Internal Limiting Membrane Dehiscence. Journal of Clinical Medicine. 2020; 9(8):2470. https://doi.org/10.3390/jcm9082470
Chicago/Turabian StyleLee, Min-Woo, Il Jung, Yong-Yeon Song, Seung-Kook Baek, and Young-Hoon Lee. 2020. "Long-Term Outcome of Epiretinal Membrane Surgery in Patients with Internal Limiting Membrane Dehiscence" Journal of Clinical Medicine 9, no. 8: 2470. https://doi.org/10.3390/jcm9082470
APA StyleLee, M.-W., Jung, I., Song, Y.-Y., Baek, S.-K., & Lee, Y.-H. (2020). Long-Term Outcome of Epiretinal Membrane Surgery in Patients with Internal Limiting Membrane Dehiscence. Journal of Clinical Medicine, 9(8), 2470. https://doi.org/10.3390/jcm9082470