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Review

Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment

1
Department of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania
2
The Research Institute of the University of Bucharest, 050663 Bucharest, Romania
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(7), 2228; https://doi.org/10.3390/jcm9072228
Received: 26 June 2020 / Revised: 10 July 2020 / Accepted: 13 July 2020 / Published: 14 July 2020
(This article belongs to the Special Issue Current Advances on Non-Melanoma Skin Cancer)
Cutaneous squamous cell carcinoma (cSCC) is a common type of neoplasia, representing a terrible burden on patients’ life and clinical management. Although it seldom metastasizes, and most cases can be effectively treated with surgical intervention, once metastatic cSCC displays considerable aggressiveness leading to the death of affected individuals. No consensus has been reached as to which features better characterize the aggressive behavior of cSCC, an achievement hindered by the high mutational burden caused by chronic ultraviolet light exposure. Even though some subtypes have been recognized as high risk variants, depending on certain tumor features, cSCC that are normally thought of as low risk could pose an increased danger to the patients. In light of this, specific genetic and epigenetic markers for cutaneous SCC, which could serve as reliable diagnostic markers and possible targets for novel treatment development, have been searched for. This review aims to give an overview of the mutational landscape of cSCC, pointing out established biomarkers, as well as novel candidates, and future possible molecular therapies for cSCC. View Full-Text
Keywords: cutaneous squamous cell carcinoma; ultraviolet radiation; genes; microRNAs; lncRNAs; novel therapeutic approaches cutaneous squamous cell carcinoma; ultraviolet radiation; genes; microRNAs; lncRNAs; novel therapeutic approaches
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MDPI and ACS Style

Lazar, A.D.; Dinescu, S.; Costache, M. Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment. J. Clin. Med. 2020, 9, 2228. https://doi.org/10.3390/jcm9072228

AMA Style

Lazar AD, Dinescu S, Costache M. Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment. Journal of Clinical Medicine. 2020; 9(7):2228. https://doi.org/10.3390/jcm9072228

Chicago/Turabian Style

Lazar, Andreea D., Sorina Dinescu, and Marieta Costache. 2020. "Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment" Journal of Clinical Medicine 9, no. 7: 2228. https://doi.org/10.3390/jcm9072228

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