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Open AccessArticle

Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data

1
Department of Dermatology, Miguel Servet University Hospital, IIS Aragón, 50009 Zaragoza, Spain
2
Department of Dermatology, University of Zaragoza, 50009 Zaragoza, Spain
3
EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Health Services Research on Chronic Patients Network (REDISSEC), Miguel Servet University Hospital, 50009 Zaragoza, Spain
4
Teaching Unit of Preventive Medicine and Public Health, Miguel Servet University Hospital, 50009 Zaragoza, Spain
*
Author to whom correspondence should be addressed.
These authors have equal contributed to this work.
J. Clin. Med. 2020, 9(6), 1632; https://doi.org/10.3390/jcm9061632
Received: 28 April 2020 / Revised: 20 May 2020 / Accepted: 25 May 2020 / Published: 28 May 2020
(This article belongs to the Special Issue Management of Atopic Dermatitis)
This study aimed at exploring atopic dermatitis (AD) prevalence in children and exhaustively analyzing their comorbidity. We conducted a descriptive analysis of their socio-demographic and comorbidity characteristics in the EpiChron Cohort (Aragón, Spain). Adjusted odds ratios (OR) were calculated for each comorbidity using logistic regression models. In total, 33,591 children had a diagnosis of AD, resulting in an overall prevalence of 15.5%. AD prevalence was higher in girls compared to boys, in 3–9-year-olds compared to children of other ages, and in Spanish children compared to those of other nationalities. Multimorbidity was present in 43% of children, with the most frequent chronic comorbidities being asthma (13.1%), psychosocial disorders (7.9%), and visual impairment (7.8%). Many diseases were, regardless of their prevalence, statistically associated with AD. The strongest associations (odds ratio (OR) (95% confidence interval (CI))) were found in asthma (2.10 (2.02–2.17)), allergic rhinitis (2.00 (1.91–2.10)), and irritable bowel syndrome (1.90 (1.56–2.31)). A better understanding of the array of comorbidities associated with AD in children might help improve their clinical management. Future longitudinal studies are encouraged to shed light on the potential underlying pathophysiological mechanisms involved in the identified associations. View Full-Text
Keywords: atopic dermatitis; children; comorbidity; multimorbidity; prevalence; Spain atopic dermatitis; children; comorbidity; multimorbidity; prevalence; Spain
MDPI and ACS Style

Gilaberte, Y.; Pérez-Gilaberte, J.B.; Poblador-Plou, B.; Bliek-Bueno, K.; Gimeno-Miguel, A.; Prados-Torres, A. Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data. J. Clin. Med. 2020, 9, 1632. https://doi.org/10.3390/jcm9061632

AMA Style

Gilaberte Y, Pérez-Gilaberte JB, Poblador-Plou B, Bliek-Bueno K, Gimeno-Miguel A, Prados-Torres A. Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data. Journal of Clinical Medicine. 2020; 9(6):1632. https://doi.org/10.3390/jcm9061632

Chicago/Turabian Style

Gilaberte, Yolanda; Pérez-Gilaberte, Juan B.; Poblador-Plou, Beatriz; Bliek-Bueno, Kevin; Gimeno-Miguel, Antonio; Prados-Torres, Alexandra. 2020. "Prevalence and Comorbidity of Atopic Dermatitis in Children: A Large-Scale Population Study Based on Real-World Data" J. Clin. Med. 9, no. 6: 1632. https://doi.org/10.3390/jcm9061632

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