Next Article in Journal
Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass: A Follow-Up Study in Middle-Aged Finnish Women
Previous Article in Journal
Association between Periodontal Diseases and Polycystic Ovary Syndrome: A Systematic Review
Open AccessArticle

Development and Validation of a Risk Score to Predict Low Birthweight Using Characteristics of the Mother: Analysis from BUNMAP Cohort in Ethiopia

1
Global Health Institute, Faculty of Medicine and Health Sciences, University of Antwerp, 2160 Antwerp, Belgium
2
Department of Nutrition and Dietetics, School of Public Health, Addis Ababa University, Addis Ababa 1000, Ethiopia
3
Department of Reproductive, Family and Population Health, School of Public Health, Addis Ababa University, Addis Ababa 1000, Ethiopia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(5), 1587; https://doi.org/10.3390/jcm9051587
Received: 2 April 2020 / Revised: 14 May 2020 / Accepted: 19 May 2020 / Published: 23 May 2020
(This article belongs to the Section Obstetrics & Gynecology)
At least one ultrasound is recommended to predict fetal growth restriction and low birthweight earlier in pregnancy. However, in low-income countries, imaging equipment and trained manpower are scarce. Hence, we developed and validated a model and risk score to predict low birthweight using maternal characteristics during pregnancy, for use in resource limited settings. We developed the model using a prospective cohort of 379 pregnant women in South Ethiopia. A stepwise multivariable analysis was done to develop the prediction model. To improve the clinical utility, we developed a simplified risk score to classify pregnant women at high- or low-risk of low birthweight. The accuracy of the model was evaluated using the area under the receiver operating characteristic curve (AUC) and calibration plot. All accuracy measures were internally validated using the bootstrapping technique. We evaluated the clinical impact of the model using a decision curve analysis across various threshold probabilities. Age at pregnancy, underweight, anemia, height, gravidity, and presence of comorbidity remained in the final multivariable prediction model. The AUC of the model was 0.83 (95% confidence interval: 0.78 to 0.88). The decision curve analysis indicated the model provides a higher net benefit across ranges of threshold probabilities. In general, this study showed the possibility of predicting low birthweight using maternal characteristics during pregnancy. The model could help to identify pregnant women at higher risk of having a low birthweight baby. This feasible prediction model would offer an opportunity to reduce obstetric-related complications, thus improving the overall maternal and child healthcare in low- and middle-income countries. View Full-Text
Keywords: prediction; model; risk score; low birthweight; pregnant women; decision curve analysis prediction; model; risk score; low birthweight; pregnant women; decision curve analysis
Show Figures

Figure 1

MDPI and ACS Style

Hassen, H.Y.; Gebreyesus, S.H.; Endris, B.S.; Roro, M.A.; Van Geertruyden, J.-P. Development and Validation of a Risk Score to Predict Low Birthweight Using Characteristics of the Mother: Analysis from BUNMAP Cohort in Ethiopia. J. Clin. Med. 2020, 9, 1587.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop