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Article
Peer-Review Record

Outcomes after Complicated and Uncomplicated Mild Traumatic Brain Injury at Three-and Six-Months Post-Injury: Results from the CENTER-TBI Study

J. Clin. Med. 2020, 9(5), 1525; https://doi.org/10.3390/jcm9051525
by Daphne C. Voormolen 1,*,†, Marina Zeldovich 2,*,†, Juanita A. Haagsma 1,3, Suzanne Polinder 1, Sarah Friedrich 4, Andrew I. R. Maas 5,6, Lindsay Wilson 7, Ewout W. Steyerberg 1,8, Amra Covic 2, Nada Andelic 9,10, Anne Marie Plass 2, Yi-Jhen Wu 2, Thomas Asendorf 4, Nicole von Steinbüechel 2 and CENTER-TBI Participants Investigators
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
J. Clin. Med. 2020, 9(5), 1525; https://doi.org/10.3390/jcm9051525
Submission received: 8 April 2020 / Revised: 11 May 2020 / Accepted: 15 May 2020 / Published: 18 May 2020
(This article belongs to the Section Clinical Neurology)

Round 1

Reviewer 1 Report

This paper is well-written with validated study method and design although clinical significance would be limited due to simple comparison among groups based on the presence or absence of intracranial abnormal findings. Finding out specific risk factors for the impairment would be much more interesting, however, I think the current form would be acceptable for publication.

Author Response

Please see the attachment. 

Author Response File: Author Response.docx

 

Reviewer 2 Report

This is a well-designed study that addresses an important clinical question with direct relevance to clinical practitioners. The manuscript is cleanly organized and well-written. The tables and figures are useful. My only suggestion would be to please more clearly describe how you accounted for the baseline differences in demographic variables (age, working status) between complicated and uncomplicated mTBI groups in your quality of life and functional outcome results.

Also line 240 typo - "after with"

Author Response

Please see the attachment.

 

Reviewer 3 Report

My only comment would be to address the implication of post-concussion treatment that does not appear to be either gathered or mentioned in the limitations. 

Also, on line #395, there appears to be an extra word (be). 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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