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Open AccessFeature PaperReview

Use of Saliva for Diagnosis and Monitoring the SARS-CoV-2: A General Perspective

Interdisciplinary Laboratory of Clinical Analysis, Interlab-UMU, Regional Campus of International Excellence ‘Campus Mare Nostrum’, University of Murcia, Espinardo, 30100 Murcia, Spain
Mediterranean Institute for Agriculture, Environment and Development (MED), Advanced Research and Training Institute (IIFA), University of Évora, 7006-554 Évora, Portugal
Department Stomatology School of Medicine, Biomedical Research Institute (IMIB-Arrixaca), Faculty of Medicine and Odontology, University of Murcia, 30008 Adv Marques de los Velez s/n, Spain
Department of Biology, School of Sciences and Technology. Mediterranean Institute for Agriculture, Environment and Development (MED). University of Évora, 7006-554 Évora, Portugal
Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Bearsden Rd, Glasgow G61 1QH, UK
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(5), 1491;
Received: 21 April 2020 / Revised: 8 May 2020 / Accepted: 11 May 2020 / Published: 15 May 2020
(This article belongs to the Special Issue COVID-19: From Pathophysiology to Clinical Practice)
In this report, updated information and future perspectives about the use of saliva as a sample for laboratory analysis of the Covid-19 are highlighted. Saliva can be used for the direct detection of the SARS-CoV-2 virus, the quantification of the specific immunoglobulins produced against it, and for the evaluation of the non-specific, innate immune response of the patient. Moreover, a deeper knowledge of potential changes in the saliva proteome in this disease may allow the identification of new diagnostic and prognostic biomarkers, or even help our understanding of the mechanisms associated with the disease. With the development of appropriate sample collection and processing methods and the use of adequate assays, saliva can provide useful clinical information about the disease and could be potentially included in guidelines for sample collection for the diagnosis, disease management, and control of Covid-19. View Full-Text
Keywords: saliva; coronavirus; SARS; Covid-19 saliva; coronavirus; SARS; Covid-19
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Ceron, J.J.; Lamy, E.; Martinez-Subiela, S.; Lopez-Jornet, P.; Capela-Silva, F.; Eckersall, P.D.; Tvarijonaviciute, A. Use of Saliva for Diagnosis and Monitoring the SARS-CoV-2: A General Perspective. J. Clin. Med. 2020, 9, 1491.

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