Prognostic Implications of Combined Imaging and Histologic Criteria in Squamous Cell Carcinoma with Mandibular Invasion
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Population
2.2. Image Analysis
2.2.1. Imaging Type Classification
2.2.2. MC Involvement
2.3. Combined Staging Based on the Imaging Type–Histologic Grade (IH Grade)
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Conflicts of Interest
References
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Characteristic | Value |
---|---|
Age (years, mean ± SD) | 61.0 ± 12.5 |
Sex | |
Female | 26 (40) |
Male | 39 (60) |
T-stage | |
1 | 5 (8) |
2 | 10 (15) |
3 | 3 (5) |
4 | 47 (72) |
Lymph node metastasis | |
No | 46 (71) |
Yes | 19 (29) |
Histologic grade | |
Well-differentiated | 23 (35) |
Moderately-differentiated | 36 (56) |
Poorly differentiated | 6 (9) |
Perineural invasion | |
Yes | 16 (24) |
No | 49 (75) |
Lymphovascular invasion | |
Yes | 11 (16) |
No | 54 (83) |
Imaging type | |
Type I | 37 (57) |
Type II | 23 (35) |
Type III | 4 (8) |
MC involvement | |
Yes | 25 (38) |
No | 40 (62) |
Surgical procedure | |
Marginal resection | 17 (26) |
Segmental resection | 43 (66) |
Hemi/Total resection | 5 (8) |
Postoperative radiation therapy | |
Yes | 32 (49) |
No | 33 (51) |
MC Involvement (Imaging) | Perineural Invasion (Histopathology) | Imaging Type | IH Grade | T-Stage | |
---|---|---|---|---|---|
Locoregional recurrence | 0.61 (0.47–0.73) | 0.58 (0.50–0.68) | 0.63 (0.49–0.73) | 0.69 (0.57–0.80) | 0.57 (0.48–0.66) |
Death a | 0.68 (0.54–0.81) | 0.63 (0.51–0.77) | 0.69 (0.53–0.84) | 0.69 (0.57–0.80) | 0.60 (0.49–0.69) |
Variable | LR | OS | ||
---|---|---|---|---|
HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
MC involvement (imaging) | 1.84 (0.74–4.55) | 0.187 | 3.47 (1.12–10.73) | 0.031 |
Perineural invasion (histopathology) | 1.95 (0.73–5.26) | 0.187 | 3.14 (0.98–10.03) | 0.053 |
Image type | ||||
II vs. I | 1.88 (0.73–4.9) | 0.196 | 2.05 (0.59–7.10) | 0.257 |
III vs. I | 2.44 (0.51–11.58) | 0.262 | 9.39 (2.14–41.18) | 0.003 |
IH grade | ||||
2 vs. 1 | 0.78 (0.22–2.68) | 0.687 | N/A a | |
3 vs. 1 | 2.85 (0.84–9.71) | 0.094 | ||
T-stage | ||||
2 vs. 1 | 0.52 (0.07–3.70) | 0.511 | 0.49 (0.03–7.85) | 0.615 |
3/4 vs. 1 | 1.06 (0.24–4.70) | 0.941 | 1.72 (0.22–13.44) | 0.605 |
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Lee, C.; Choi, Y.J.; Jeon, K.J.; Kim, D.W.; Nam, W.; Kim, H.J.; Cha, I.-H.; Han, S.S. Prognostic Implications of Combined Imaging and Histologic Criteria in Squamous Cell Carcinoma with Mandibular Invasion. J. Clin. Med. 2020, 9, 1335. https://doi.org/10.3390/jcm9051335
Lee C, Choi YJ, Jeon KJ, Kim DW, Nam W, Kim HJ, Cha I-H, Han SS. Prognostic Implications of Combined Imaging and Histologic Criteria in Squamous Cell Carcinoma with Mandibular Invasion. Journal of Clinical Medicine. 2020; 9(5):1335. https://doi.org/10.3390/jcm9051335
Chicago/Turabian StyleLee, Chena, Yoon Joo Choi, Kug Jin Jeon, Dong Wook Kim, Woong Nam, Hyung Jun Kim, In-Ho Cha, and Sang Sun Han. 2020. "Prognostic Implications of Combined Imaging and Histologic Criteria in Squamous Cell Carcinoma with Mandibular Invasion" Journal of Clinical Medicine 9, no. 5: 1335. https://doi.org/10.3390/jcm9051335
APA StyleLee, C., Choi, Y. J., Jeon, K. J., Kim, D. W., Nam, W., Kim, H. J., Cha, I.-H., & Han, S. S. (2020). Prognostic Implications of Combined Imaging and Histologic Criteria in Squamous Cell Carcinoma with Mandibular Invasion. Journal of Clinical Medicine, 9(5), 1335. https://doi.org/10.3390/jcm9051335