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Changes in Respiratory Muscle Strength Following Cardiac Rehabilitation for Prognosis in Patients with Heart Failure
Review

Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement

1
Department of Translational Medical Sciences, “Federico II” University of Naples, 80131 Naples, Italy
2
Department of Clinical Medicine and Surgery, “Federico II” University of Naples, 80131 Naples, Italy
3
Cardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, 90123 Palermo, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(5), 1266; https://doi.org/10.3390/jcm9051266
Received: 5 April 2020 / Revised: 19 April 2020 / Accepted: 24 April 2020 / Published: 27 April 2020
(This article belongs to the Special Issue Cardiovascular Rehabilitation)
Oxidative stress and mitochondrial dysfunction are hallmarks of heart failure (HF). Coenzyme Q10 (CoQ10) is a vitamin-like organic compound widely expressed in humans as ubiquinol (reduced form) and ubiquinone (oxidized form). CoQ10 plays a key role in electron transport in oxidative phosphorylation of mitochondria. CoQ10 acts as a potent antioxidant, membrane stabilizer and cofactor in the production of adenosine triphosphate by oxidative phosphorylation, inhibiting the oxidation of proteins and DNA. Patients with HF showed CoQ10 deficiency; therefore, a number of clinical trials investigating the effects of CoQ10 supplementation in HF have been conducted. CoQ10 supplementation may confer potential prognostic advantages in HF patients with no adverse hemodynamic profile or safety issues. The latest evidence on the clinical effects of CoQ10 supplementation in HF was reviewed. View Full-Text
Keywords: heart failure; coenzyme Q10; coenzyme Q10 deficiency; coenzyme Q10 supplementation; heart failure mortality heart failure; coenzyme Q10; coenzyme Q10 deficiency; coenzyme Q10 supplementation; heart failure mortality
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MDPI and ACS Style

Di Lorenzo, A.; Iannuzzo, G.; Parlato, A.; Cuomo, G.; Testa, C.; Coppola, M.; D’Ambrosio, G.; Oliviero, D.A.; Sarullo, S.; Vitale, G.; Nugara, C.; Sarullo, F.M.; Giallauria, F. Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement. J. Clin. Med. 2020, 9, 1266. https://doi.org/10.3390/jcm9051266

AMA Style

Di Lorenzo A, Iannuzzo G, Parlato A, Cuomo G, Testa C, Coppola M, D’Ambrosio G, Oliviero DA, Sarullo S, Vitale G, Nugara C, Sarullo FM, Giallauria F. Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement. Journal of Clinical Medicine. 2020; 9(5):1266. https://doi.org/10.3390/jcm9051266

Chicago/Turabian Style

Di Lorenzo, Anna, Gabriella Iannuzzo, Alessandro Parlato, Gianluigi Cuomo, Crescenzo Testa, Marta Coppola, Giuseppe D’Ambrosio, Domenico A. Oliviero, Silvia Sarullo, Giuseppe Vitale, Cinzia Nugara, Filippo M. Sarullo, and Francesco Giallauria. 2020. "Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement" Journal of Clinical Medicine 9, no. 5: 1266. https://doi.org/10.3390/jcm9051266

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