Association between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels
Abstract
:1. Introduction
2. Methods
2.1. Clinical and Biochemical Assessment
2.2. Lipoprotein Determination
2.3. High-Resolution Carotid Ultrasound
3. Statistical Analysis
4. Results
5. Discussion
Author Contributions
Conflicts of Interest
References
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n = 75 | |
---|---|
Age (years) | 61.2 ± 9.3 |
Total cholesterol (mg/dL) | 187.4 ± 20.9 |
Triglycerides (mg/dL) | 96.9 ± 41.1 |
High-density lipoprotein cholesterol (mg/dL) | 59.4 ± 14.8 |
Low-density lipoprotein cholesterol (mg/dL) | 108.6 ± 15.3 |
Fasting glucose (mg/dL) | 102.8 ± 20.0 |
Apolipoprotein B (g/L) | 0.9 ± 0.1 |
Lipoprotein a (mg/dL) | 18.6 ± 23.6 |
Low-density lipoprotein (LDL) score (mg/dL) | 2.4 ± 4.4 |
Mean LDL diameter (Å) | 271.2 ± 3.0 |
High sensitive C-reactive protein (CRP) (mg/L) | 3.4 ± 6.0 |
Creatinine (mg/dL) | 0.8 ± 0.1 |
Body mass index (kg/m2) | 27.9 ± 5.4 |
Waist circumference (cm) | 89.1± 11.7 |
Homeostatic assessment model index (HOMA) | 1.8 ± 1.3 |
Systolic blood pressure (mm Hg) | 141.4 ± 24.3 |
Diastolic blood pressure (mm Hg) | 80.4 ± 9.8 |
Intima-media thickness (mm) | 1.0 ± 0.2 |
Active smokers (yes/not) | 29.5% |
OR | 95%CI | p Value | OR | 95%CI | p Value | |
---|---|---|---|---|---|---|
tertile II vs. tertile I (reference) | tertile III vs. tertile I (reference) | |||||
HDL-C | 0.54 | 0.14–2.16 | 0.38 | 0.52 | 0.13–2.04 | 0.35 |
LDL-C | 1.27 | 0.25–6.40 | 0.77 | 2.81 | 0.65–12.18 | 0.17 |
IDL-C | 2.33 | 0.51–10.69 | 0.27 | 2.00 | 0.44–9.07 | 0.37 |
VLDL-C | 2.56 | 0.58–11.29 | 0.21 | 5.64 | 1.30–24.31 | 0.02 |
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Gentile, M.; Iannuzzi, A.; Giallauria, F.; D’Andrea, A.; Venturini, E.; Pacileo, M.; Covetti, G.; Panico, C.; Mattiello, A.; Vitale, G.; et al. Association between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels. J. Clin. Med. 2020, 9, 1422. https://doi.org/10.3390/jcm9051422
Gentile M, Iannuzzi A, Giallauria F, D’Andrea A, Venturini E, Pacileo M, Covetti G, Panico C, Mattiello A, Vitale G, et al. Association between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels. Journal of Clinical Medicine. 2020; 9(5):1422. https://doi.org/10.3390/jcm9051422
Chicago/Turabian StyleGentile, Marco, Arcangelo Iannuzzi, Francesco Giallauria, Antonello D’Andrea, Elio Venturini, Mario Pacileo, Giuseppe Covetti, Camilla Panico, Amalia Mattiello, Giuseppe Vitale, and et al. 2020. "Association between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels" Journal of Clinical Medicine 9, no. 5: 1422. https://doi.org/10.3390/jcm9051422