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Article

Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial

1
Infectious Diseases Department, Hospital Universitari Vall d’Hebron, 08035 Barcelona, Spain
2
Vall d’Hebron Institut de Recerca (VHIR), 085035 Barcelona, Spain
3
Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, 43005 Tarragona, Spain
4
Department of Internal Medicine - Hepatology, Hospital Universitari Vall d’Hebron (HUVH), 08035 Barcelona, Spain
5
Internal Medicine Department. Complexo Hospitalario Universitario de Vigo; IIS Galicia Sur, 36312 Vigo, Spain
*
Author to whom correspondence should be addressed.
The first two authors contribute equally for this work.
J. Clin. Med. 2020, 9(5), 1246; https://doi.org/10.3390/jcm9051246
Received: 20 March 2020 / Revised: 14 April 2020 / Accepted: 22 April 2020 / Published: 25 April 2020
(This article belongs to the Section Infectious Diseases)
HIV and antiretroviral therapy affect lipid metabolism. Lipidomics quantifies several individual species that are overlooked using conventional biochemical analyses, outperforming traditional risk equations. We aimed to compare the plasma lipidomic profile of HIV patients taking efavirenz (EFV) or rilpivirine (RPV). Patients ≥ 18 years old on EFV co-formulated with emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) with HIV-RNA < 50 copies/mL for ≥6 months were randomized to continue EFV/FTC/TDF (n = 14) or switch to RPV/FTC/TDF (n =15). Lipidomic analyses conducted by mass spectrometry (MS) were performed at baseline and after 12 and 24 weeks. OWLiver® Care and OWLiver® tests were performed to estimate the presence of fatty liver disease (NAFLD). No significant differences (83% male, median age 44 years, 6 years receiving EFV/FTC/TDF, CD4+ count 740 cells/mm3, TC 207 [57 HDL-C/133 LDL-C] mg/dL, TG 117 mg/dL) were observed between the groups at baseline. Significant reductions in plasma lipids and lipoproteins but increased circulating bilirubin concentrations were observed in patients who switched to RPV/FTC/TDF. Patients on RPV/FTC/TDF showed a decrease in the global amount of storage lipids (-0.137 log2 [fold-change] EFV vs. 0.059 log2 [fold-change] RPV) but an increase in lysophosphatidylcholines (LPCs) and total steroids. Compared with EFV, RPV increased metabolites with anti-inflammatory properties and reduced the repository of specific lipotoxic lipids. View Full-Text
Keywords: lipidomics; NAFLD; efavirenz; rilpivirine; switch lipidomics; NAFLD; efavirenz; rilpivirine; switch
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MDPI and ACS Style

Curran, A.; Rull, A.; Navarro, J.; Vidal-González, J.; Martin-Castillo, M.; Burgos, J.; Falcó, V.; Ribera, E.; Torrella, A.; Planas, B.; Peraire, J.; Crespo, M. Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial. J. Clin. Med. 2020, 9, 1246. https://doi.org/10.3390/jcm9051246

AMA Style

Curran A, Rull A, Navarro J, Vidal-González J, Martin-Castillo M, Burgos J, Falcó V, Ribera E, Torrella A, Planas B, Peraire J, Crespo M. Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial. Journal of Clinical Medicine. 2020; 9(5):1246. https://doi.org/10.3390/jcm9051246

Chicago/Turabian Style

Curran, Adrian, Anna Rull, Jordi Navarro, Judit Vidal-González, Mario Martin-Castillo, Joaquin Burgos, Vicenç Falcó, Esteban Ribera, Ariadna Torrella, Bibiana Planas, Joaquim Peraire, and Manuel Crespo. 2020. "Lipidomics Reveals Reduced Inflammatory Lipid Species and Storage Lipids after Switching from EFV/FTC/TDF to RPV/FTC/TDF: A Randomized Open-Label Trial" Journal of Clinical Medicine 9, no. 5: 1246. https://doi.org/10.3390/jcm9051246

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