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Peripheral Blood Mononuclear Cells and Platelets Mitochondrial Dysfunction, Oxidative Stress, and Circulating mtDNA in Cardiovascular Diseases

1
Unistra, Translational Medicine Federation of Strasbourg (FMTS), Faculty of Medicine, Team 3072 “Mitochondria, Oxidative Stress and Muscle Protection”, 11 rue Humann, 67000 Strasbourg, France
2
University Hospital of Strasbourg, Physiology and Functional Exploration Service, 1 Place de l’Hôpital, 67091 Strasbourg CEDEX, France
3
Internal Medicine, Diabete and Metabolic Diseases Service, University Hospital of Strasbourg, 1 Place de l’Hôpital, 67091 Strasbourg CEDEX, France
4
Vascular Surgery and Kidney Transplantation Service, University Hospital of Strasbourg, 1 Place de l’Hôpital, 67091 Strasbourg CEDEX, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(2), 311; https://doi.org/10.3390/jcm9020311
Received: 31 December 2019 / Revised: 16 January 2020 / Accepted: 19 January 2020 / Published: 22 January 2020
(This article belongs to the Special Issue Novel Biomarkers for Heart Disease)
Cardiovascular diseases (CVDs) are devastating disorders and the leading cause of mortality worldwide. The pathophysiology of cardiovascular diseases is complex and multifactorial and, in the past years, mitochondrial dysfunction and excessive production of reactive oxygen species (ROS) have gained growing attention. Indeed, CVDs can be considered as a systemic alteration, and understanding the eventual implication of circulating blood cells peripheral blood mononuclear cells (PBMCs) and or platelets, and particularly their mitochondrial function, ROS production, and mitochondrial DNA (mtDNA) releases in patients with cardiac impairments, appears worthwhile. Interestingly, reports consistently demonstrate a reduced mitochondrial respiratory chain oxidative capacity related to the degree of CVD severity and to an increased ROS production by PBMCs. Further, circulating mtDNA level was generally modified in such patients. These data are critical steps in term of cardiac disease comprehension and further studies are warranted to challenge the possible adjunct of PBMCs’ and platelets’ mitochondrial dysfunction, oxidative stress, and circulating mtDNA as biomarkers of CVD diagnosis and prognosis. This new approach might also allow further interesting therapeutic developments. View Full-Text
Keywords: cardiovascular diseases; mitochondrial dysfunction; circulating cells; PBMCS; platelets; oxidative stress; reactive oxygen species (ROS); mitochondrial DNA (mtDNA); biomarkers; herat failure cardiovascular diseases; mitochondrial dysfunction; circulating cells; PBMCS; platelets; oxidative stress; reactive oxygen species (ROS); mitochondrial DNA (mtDNA); biomarkers; herat failure
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MDPI and ACS Style

Alfatni, A.; Riou, M.; Charles, A.-L.; Meyer, A.; Barnig, C.; Andres, E.; Lejay, A.; Talha, S.; Geny, B. Peripheral Blood Mononuclear Cells and Platelets Mitochondrial Dysfunction, Oxidative Stress, and Circulating mtDNA in Cardiovascular Diseases. J. Clin. Med. 2020, 9, 311. https://doi.org/10.3390/jcm9020311

AMA Style

Alfatni A, Riou M, Charles A-L, Meyer A, Barnig C, Andres E, Lejay A, Talha S, Geny B. Peripheral Blood Mononuclear Cells and Platelets Mitochondrial Dysfunction, Oxidative Stress, and Circulating mtDNA in Cardiovascular Diseases. Journal of Clinical Medicine. 2020; 9(2):311. https://doi.org/10.3390/jcm9020311

Chicago/Turabian Style

Alfatni, Abrar; Riou, Marianne; Charles, Anne-Laure; Meyer, Alain; Barnig, Cindy; Andres, Emmanuel; Lejay, Anne; Talha, Samy; Geny, Bernard. 2020. "Peripheral Blood Mononuclear Cells and Platelets Mitochondrial Dysfunction, Oxidative Stress, and Circulating mtDNA in Cardiovascular Diseases" J. Clin. Med. 9, no. 2: 311. https://doi.org/10.3390/jcm9020311

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