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Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study

1
Department of Internal Medicine, Angers University Hospital, 4 Rue Larrey, 49000 Angers, France
2
Department of Biochemistry and Genetics, Angers University Hospital, 4 Rue Larrey, 49000 Angers, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 4063; https://doi.org/10.3390/jcm9124063
Received: 11 November 2020 / Revised: 5 December 2020 / Accepted: 14 December 2020 / Published: 16 December 2020
(This article belongs to the Section Dermatology)
Descriptive and retrospective studies without control groups have suggested a possible association between primary Sjögren’s syndrome (pSS) and vitamin B12 (B12) deficiency. This is of importance because several mucosal and neurological features are common to these two conditions and could be prevented or reversed in case of B12 deficiency. We aimed to evaluate the association between pSS and B12 deficiency. We prospectively assessed the B12 status of 490 patients hospitalized in an internal medicine department over a 15-week period. Patients with pernicious anemia were excluded. We extracted patients with pSS and paired them with controls according to age and sex, with a 1:5 ratio. Twenty-one pSS patients were paired with 105 control patients. The median age was 70 years old (51–75) and 95.2% of patients were women. The plasma B12 level was lower in pSS patients (329 (293–521) ng/L vs. 456 (341–587) ng/L, p < 0.0001). B12 deficiency was associated with pSS (42.9% among pSS patients vs. 11.4% among controls), even after adjustment for other causes of B12 deficiency (OR 6.45 (95%CI: 2.08–20.0)). In conclusion, pSS appeared to be associated with B12 deficiency, even after the exclusion of pernicious anemia. This justifies screening and treating B12 deficiency in pSS patients. View Full-Text
Keywords: vitamin B12; Sjögren’s syndrome; vitamin B12 deficiency; haptocorrin vitamin B12; Sjögren’s syndrome; vitamin B12 deficiency; haptocorrin
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MDPI and ACS Style

Urbanski, G.; Chabrun, F.; Schaepelynck, B.; May, M.; Loiseau, M.; Schlumberger, E.; Delattre, E.; Lavigne, C.; Lacombe, V. Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study. J. Clin. Med. 2020, 9, 4063. https://doi.org/10.3390/jcm9124063

AMA Style

Urbanski G, Chabrun F, Schaepelynck B, May M, Loiseau M, Schlumberger E, Delattre E, Lavigne C, Lacombe V. Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study. Journal of Clinical Medicine. 2020; 9(12):4063. https://doi.org/10.3390/jcm9124063

Chicago/Turabian Style

Urbanski, Geoffrey, Floris Chabrun, Baudouin Schaepelynck, Morgane May, Marianne Loiseau, Esther Schlumberger, Estelle Delattre, Christian Lavigne, and Valentin Lacombe. 2020. "Association of Primary Sjögren’s Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study" Journal of Clinical Medicine 9, no. 12: 4063. https://doi.org/10.3390/jcm9124063

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