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Article

Impact of Pulse Wave Velocity and Parameters Reflecting Android Type Fat Distribution on Left Ventricular Diastolic Dysfunction in Patients with Chronic Coronary Syndromes

1
Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, 15-269 Bialystok, Poland
2
Department of Invasive Cardiology, Medical University of Bialystok, 15-269 Bialystok, Poland
3
Department of Cardiology, Medical University of Bialystok, 15-269 Bialystok, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 3924; https://doi.org/10.3390/jcm9123924
Received: 16 November 2020 / Revised: 27 November 2020 / Accepted: 1 December 2020 / Published: 3 December 2020
(This article belongs to the Special Issue Recent Advances in Coronary Artery Disease)
Background: Left ventricular diastolic dysfunction (LVDD) is caused by a decreased left ventricle relaxation and is associated with an increased risk of symptomatic heart failure (HF) and excessive mortality. Aim: To evaluate the frequency and factors related to LVDD in the population with chronic coronary syndromes (CCS). Methods: 200 patients (mean age 63.18 ± 8.12 years, 75.5% male) with CCS were included. LVDD was diagnosed based on the recent echocardiography guidelines. Results: LVDD was diagnosed in 38.5% of CCS population. From the studied factors, after adjustment for age, sex, and N-terminal pro-brain natriuretic peptide (NT-proBNP), LVDD associated positively with android/gynoid (A/G) fat mass ratio, left ventricular mass index (LVMI), and negatively with Z-score and left ventricular ejection fraction (LVEF). In stepwise backward logistic regression analysis, the strongest factors associated with LVDD were pulse wave velocity value, handgrip strength and waist to hip ratio (WHR). Conclusions: LVDD is common among CCS patients and it is associated with parameters reflecting android type fat distribution regardless of NT-proBNP and high-sensitivity troponin T concentrations. Deterioration in diastolic dysfunction is linked with increased aortic stiffness independently of age and sex. Further studies evaluating the effects of increasing physical fitness and lowering abdominal fat accumulations on LVDD in CCS patients should be considered. View Full-Text
Keywords: left ventricular diastolic dysfunction; android fat distribution; chronic coronary syndromes left ventricular diastolic dysfunction; android fat distribution; chronic coronary syndromes
MDPI and ACS Style

Paniczko, M.; Chlabicz, M.; Jamiołkowski, J.; Sowa, P.; Szpakowicz, M.; Łapińska, M.; Kondraciuk, M.; Ptaszyńska-Kopczyńska, K.; Raczkowski, A.; Szpakowicz, A.; Kamiński, K.A. Impact of Pulse Wave Velocity and Parameters Reflecting Android Type Fat Distribution on Left Ventricular Diastolic Dysfunction in Patients with Chronic Coronary Syndromes. J. Clin. Med. 2020, 9, 3924. https://doi.org/10.3390/jcm9123924

AMA Style

Paniczko M, Chlabicz M, Jamiołkowski J, Sowa P, Szpakowicz M, Łapińska M, Kondraciuk M, Ptaszyńska-Kopczyńska K, Raczkowski A, Szpakowicz A, Kamiński KA. Impact of Pulse Wave Velocity and Parameters Reflecting Android Type Fat Distribution on Left Ventricular Diastolic Dysfunction in Patients with Chronic Coronary Syndromes. Journal of Clinical Medicine. 2020; 9(12):3924. https://doi.org/10.3390/jcm9123924

Chicago/Turabian Style

Paniczko, Marlena, Małgorzata Chlabicz, Jacek Jamiołkowski, Paweł Sowa, Małgorzata Szpakowicz, Magda Łapińska, Marcin Kondraciuk, Katarzyna Ptaszyńska-Kopczyńska, Andrzej Raczkowski, Anna Szpakowicz, and Karol A. Kamiński 2020. "Impact of Pulse Wave Velocity and Parameters Reflecting Android Type Fat Distribution on Left Ventricular Diastolic Dysfunction in Patients with Chronic Coronary Syndromes" Journal of Clinical Medicine 9, no. 12: 3924. https://doi.org/10.3390/jcm9123924

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