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Article

Diagnostic Power of Galectin-3 in Rheumatic Diseases

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Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona St. 15A, 15-269 Bialystok, Poland
2
Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona St. 17, 15-274 Bialystok, Poland
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Department of Rheumatology and Internal Diseases, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland
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Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Waszyngtona St. 15A, 15-269 Bialystok, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(10), 3312; https://doi.org/10.3390/jcm9103312
Received: 12 September 2020 / Revised: 1 October 2020 / Accepted: 13 October 2020 / Published: 15 October 2020
(This article belongs to the Section Immunology)
Background: The purpose of our study was to assess the diagnostic power of galectin-3 and compare its between rheumatic diseases and with routinely used tests such as CRP and ESR. Methods: Eighty-two patients with rheumatoid arthritis (RA), 49 patients with systemic sclerosis (SSc), and 18 patients with systemic lupus erythematosus (SLE) were enrolled in this study. The control group comprised 30 healthy controls. Serum galectin-3 concentration was measured using immunochemical method. Results: The galectin-3 concentration were significantly elevated in the RA, SSc, and SLE in comparison to the controls (p = 0.000, p = 0.000, p < 0.001; respectively). However, there were no significant differences in the serum galectin-3 levels between rheumatic diseases (H = 0.395, p = 0.821). In RA and SSc patients, galectin-3 positively correlated with erythrocyte sedimentation rate (R = 0.332, p = 0.004; R = 0.384, p = 0.009; respectively). ROC analysis revealed that galectin-3 had an excellent diagnostic power in RA (AUC = 0.911) and SSc (AUC = 0.903) and very good for SLE (AUC = 0.859). Conclusion: We concluded that diagnostic power of serum galectin-3 is as great as CRP and ESR in rheumatic diseases and it can be a very good laboratory marker in RA and SSc patients and a useful tool in the diagnosis of SLE. View Full-Text
Keywords: galectin-3; rheumatoid arthritis; systemic sclerosis; systemic lupus erythematosus galectin-3; rheumatoid arthritis; systemic sclerosis; systemic lupus erythematosus
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MDPI and ACS Style

Gruszewska, E.; Cylwik, B.; Gińdzieńska-Sieśkiewicz, E.; Kowal-Bielecka, O.; Mroczko, B.; Chrostek, L. Diagnostic Power of Galectin-3 in Rheumatic Diseases. J. Clin. Med. 2020, 9, 3312. https://doi.org/10.3390/jcm9103312

AMA Style

Gruszewska E, Cylwik B, Gińdzieńska-Sieśkiewicz E, Kowal-Bielecka O, Mroczko B, Chrostek L. Diagnostic Power of Galectin-3 in Rheumatic Diseases. Journal of Clinical Medicine. 2020; 9(10):3312. https://doi.org/10.3390/jcm9103312

Chicago/Turabian Style

Gruszewska, Ewa, Bogdan Cylwik, Ewa Gińdzieńska-Sieśkiewicz, Otylia Kowal-Bielecka, Barbara Mroczko, and Lech Chrostek. 2020. "Diagnostic Power of Galectin-3 in Rheumatic Diseases" Journal of Clinical Medicine 9, no. 10: 3312. https://doi.org/10.3390/jcm9103312

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