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Targeting the Host for New Therapeutic Perspectives in Hepatitis D

1
Inserm, Institut de Recherche sur les Maladies Virales et Hépatiques UMR_S1110, Université de Strasbourg, F-67000 Strasbourg, France
2
Institut Hospitalo-Universitaire, Pôle Hépato-Digestif, Nouvel Hôpital Civil, F-67000 Strasbourg, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 222; https://doi.org/10.3390/jcm9010222
Received: 20 December 2019 / Revised: 9 January 2020 / Accepted: 10 January 2020 / Published: 14 January 2020
Hepatitis D virus (HDV) is a small satellite virus of hepatitis B virus (HBV) requiring HBV infection to complete its life cycle. It has been recently estimated that 13% of chronic HBV infected patients (60 million) are co-infected with HDV. Chronic hepatitis D is the most severe form of viral hepatitis with the highest risk to develop cirrhosis and liver cancer. Current treatment is based on pegylated-interferon-alpha which rarely controls HDV infection and is complicated by serious side effects. The development of novel antiviral strategies based on host targeting agents has shown promising results in phase I/II clinical trials. This review summarizes HDV molecular virology and physiopathology as well as new therapeutic approaches targeting HDV host factors. View Full-Text
Keywords: Hepatitis D; antiviral strategy; host factors; liver disease Hepatitis D; antiviral strategy; host factors; liver disease
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Turon-Lagot, V.; Saviano, A.; Schuster, C.; Baumert, T.F.; Verrier, E.R. Targeting the Host for New Therapeutic Perspectives in Hepatitis D. J. Clin. Med. 2020, 9, 222.

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