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Isolated Anti-HBc: Significance and Management

Infectious Diseases Department, Dijon University Hospital, 21079 Dijon, France
INSERM CIC 1432, Module Plurithématique, University of Burgundy, 21079 Dijon, France
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 202;
Received: 9 December 2019 / Revised: 6 January 2020 / Accepted: 7 January 2020 / Published: 11 January 2020
Hepatitis B virus (HBV) infection is prevalent worldwide and is associated with dramatic levels of morbidity and mortality. Isolated anti-HBc (IAHBc) is a particular serological pattern that is commonly found in immunocompromised patients. There is ongoing debate regarding the management of patients with IAHBc. Herein, we summarize the current guidelines and the newest evidence. The frequency of IAHBc is variable, with a higher prevalence in some populations, such as persons living with HIV and others immunocompromised patients. The risk of HBV reactivation depends on host factors (including immunosuppression) and viral factors. It is now well established that immunocompromised patients can be classified into three groups for risk according to the type of immunosuppression and/or treatment. In patients at high risk, HBV therapy has to be considered systematically. In patients at moderate risk, the decision is based on the level of HBV DNA (preemptive treatment or monitoring and vaccination). In patients with low risk, HBV vaccination is another possible approach, although further studies are needed to assess the type of preemptive strategy. View Full-Text
Keywords: viral hepatitis; isolated anti-HBc antibodies; immunosuppression; hepatitis B infection; HBV reactivation; management viral hepatitis; isolated anti-HBc antibodies; immunosuppression; hepatitis B infection; HBV reactivation; management
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MORETTO, F.; CATHERINE, F.-X.; ESTEVE, C.; BLOT, M.; PIROTH, L. Isolated Anti-HBc: Significance and Management. J. Clin. Med. 2020, 9, 202.

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