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Article

Early Neurological Assessment in Infants with Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia

1
Pediatric Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
2
Pediatric Neurology Unit, Università Cattolica del Sacro Cuore Roma, 00168 Rome, Italy
3
Neonatal Intensive Care Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(8), 1247; https://doi.org/10.3390/jcm8081247
Received: 1 July 2019 / Revised: 22 July 2019 / Accepted: 12 August 2019 / Published: 18 August 2019
Early neurological assessment in infants with hypoxic ischemic encephalopathy (HIE) treated with hypothermia has not been systematically explored. The aims of the present study were to assess whether the Hammersmith Infant Neurological Examination (HINE) is a good tool to predict later neurodevelopmental outcomes at 2 year from birth in this population of infants. A total of 41 term born infants with HIE treated with hypothermia performed the HINE at 12 months and a neurodevelopmental assessment at 24 months. All the infants who had a global HINE score between 67 and 78 were able to walk independently at 2 years and reported a normal developmental quotient; language disorders were observed in a limited number of infants. HINE scores <67 were always associated with motor impairment. In conclusion, the HINE confirms its role as one of the early neurological examination tools for the diagnosis of high risk infants, even in infants with HIE treated with hypothermia. These results can be useful for clinicians involved in the follow up of these infants for early identification of motor disabilities and in planning appropriate intervention. View Full-Text
Keywords: hypoxic ischemic encephalopathy; hypothermia; Hammersmith Infant Neurological Examination; outcome hypoxic ischemic encephalopathy; hypothermia; Hammersmith Infant Neurological Examination; outcome
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MDPI and ACS Style

Romeo, D.M.; Bompard, S.; Serrao, F.; Leo, G.; Cicala, G.; Velli, C.; Gallini, F.; Priolo, F.; Vento, G.; Mercuri, E. Early Neurological Assessment in Infants with Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia. J. Clin. Med. 2019, 8, 1247. https://doi.org/10.3390/jcm8081247

AMA Style

Romeo DM, Bompard S, Serrao F, Leo G, Cicala G, Velli C, Gallini F, Priolo F, Vento G, Mercuri E. Early Neurological Assessment in Infants with Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia. Journal of Clinical Medicine. 2019; 8(8):1247. https://doi.org/10.3390/jcm8081247

Chicago/Turabian Style

Romeo, Domenico M., Sarah Bompard, Francesca Serrao, Giuseppina Leo, Gianpaolo Cicala, Chiara Velli, Francesca Gallini, Francesca Priolo, Giovanni Vento, and Eugenio Mercuri. 2019. "Early Neurological Assessment in Infants with Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia" Journal of Clinical Medicine 8, no. 8: 1247. https://doi.org/10.3390/jcm8081247

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