Next Article in Journal
Epac1 and Glycyrrhizin Both Inhibit HMGB1 Levels to Reduce Diabetes-Induced Neuronal and Vascular Damage in the Mouse Retina
Next Article in Special Issue
Systematic Review of the Long-Term Effects of Transgender Hormone Therapy on Bone Markers and Bone Mineral Density and Their Potential Effects in Implant Therapy
Previous Article in Journal
Use of Secukinumab in a Cohort of Erythrodermic Psoriatic Patients: A Pilot Study
Previous Article in Special Issue
Comparative Study between an Immediate Loading Protocol Using the Digital Workflow and a Conventional Protocol for Dental Implant Treatment: A Randomized Clinical Trial
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 8
Issue 6
10.3390/jcm8060771
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

An In Vitro Study of Osteoblast Response on Fused-Filament Fabrication 3D Printed PEEK for Dental and Cranio-Maxillofacial Implants

by
Xingting Han
1,*,
Neha Sharma
2,3,
Zeqian Xu
1,
Lutz Scheideler
1,
Jürgen Geis-Gerstorfer
1,
Frank Rupp
1,
Florian M. Thieringer
2,3,† and
Sebastian Spintzyk
1,†
1
Section Medical Materials Science and Technology, University Hospital Tübingen, Osianderstr. 2–8, D-72076 Tübingen, Germany
2
Medical Additive Manufacturing Research Group, Hightech Research Center, Department of Biomedical Engineering, University of Basel, CH-4123 Allschwil, Switzerland
3
Department of Oral and Cranio-Maxillofacial Surgery, University Hospital Basel, CH-4031 Basel, Switzerland
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(6), 771; https://doi.org/10.3390/jcm8060771
Submission received: 3 May 2019 / Revised: 28 May 2019 / Accepted: 29 May 2019 / Published: 31 May 2019
(This article belongs to the Special Issue Implant Dentistry—Trends, Challenges and Innovations)
Browse Figures
Review Reports Versions Notes

Abstract

Polyetheretherketone (PEEK) is a prime candidate to replace metallic implants and prostheses in orthopedic, spine and cranio-maxillofacial surgeries. Fused-filament fabrication (FFF) is an economical and efficient three-dimensional (3D) printing method to fabricate PEEK implants. However, studies pertaining to the bioactivity of FFF 3D printed PEEK are still lacking. In this study, FFF 3D printed PEEK samples were fabricated and modified with polishing and grit-blasting (three alumina sizes: 50, 120, and 250 µm) to achieve varying levels of surface roughness. In vitro cellular response of a human osteosarcoma cell line (SAOS-2 osteoblasts, cell adhesion, metabolic activity, and proliferation) on different sample surfaces of untreated, polished, and grit-blasted PEEK were evaluated. The results revealed that the initial cell adhesion on different sample surfaces was similar. However, after 5 days the untreated FFF 3D printed PEEK surfaces exhibited a significant increase in cell metabolic activity and proliferation with a higher density of osteoblasts compared with the polished and grit-blasted groups (p < 0.05). Therefore, untreated FFF 3D printed PEEK with high surface roughness and optimal printing structures might have great potential as an appropriate alloplastic biomaterial for reconstructive cranio-maxillofacial surgeries.
Keywords: polyetheretherketone; dental and cranio-maxillofacial implants; prostheses; fused-filament fabrication; in vitro study; surface modification and characterization; cell adhesion; cell metabolic activity; cell proliferation polyetheretherketone; dental and cranio-maxillofacial implants; prostheses; fused-filament fabrication; in vitro study; surface modification and characterization; cell adhesion; cell metabolic activity; cell proliferation
Graphical Abstract

Share and Cite

MDPI and ACS Style

Han, X.; Sharma, N.; Xu, Z.; Scheideler, L.; Geis-Gerstorfer, J.; Rupp, F.; Thieringer, F.M.; Spintzyk, S. An In Vitro Study of Osteoblast Response on Fused-Filament Fabrication 3D Printed PEEK for Dental and Cranio-Maxillofacial Implants. J. Clin. Med. 2019, 8, 771. https://doi.org/10.3390/jcm8060771

AMA Style

Han X, Sharma N, Xu Z, Scheideler L, Geis-Gerstorfer J, Rupp F, Thieringer FM, Spintzyk S. An In Vitro Study of Osteoblast Response on Fused-Filament Fabrication 3D Printed PEEK for Dental and Cranio-Maxillofacial Implants. Journal of Clinical Medicine. 2019; 8(6):771. https://doi.org/10.3390/jcm8060771

Chicago/Turabian Style

Han, Xingting, Neha Sharma, Zeqian Xu, Lutz Scheideler, Jürgen Geis-Gerstorfer, Frank Rupp, Florian M. Thieringer, and Sebastian Spintzyk. 2019. "An In Vitro Study of Osteoblast Response on Fused-Filament Fabrication 3D Printed PEEK for Dental and Cranio-Maxillofacial Implants" Journal of Clinical Medicine 8, no. 6: 771. https://doi.org/10.3390/jcm8060771

APA Style

Han, X., Sharma, N., Xu, Z., Scheideler, L., Geis-Gerstorfer, J., Rupp, F., Thieringer, F. M., & Spintzyk, S. (2019). An In Vitro Study of Osteoblast Response on Fused-Filament Fabrication 3D Printed PEEK for Dental and Cranio-Maxillofacial Implants. Journal of Clinical Medicine, 8(6), 771. https://doi.org/10.3390/jcm8060771

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop