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Effect of Ketorolac on the Prevention of Postoperative Catheter-Related Bladder Discomfort in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy: A Randomized, Double-Blinded, Placebo-Controlled Study

1
Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
2
Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
3
Department of Anesthesiology and Pain Medicine, Chosun University Hospital, Gwangju 61453, Korea
4
Department of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07247, Korea
*
Authors to whom correspondence should be addressed.
The authors contributed equally to this project as co-corresponding authors.
J. Clin. Med. 2019, 8(6), 759; https://doi.org/10.3390/jcm8060759
Received: 4 May 2019 / Revised: 17 May 2019 / Accepted: 27 May 2019 / Published: 29 May 2019
(This article belongs to the Section Nephrology & Urology)
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PDF [869 KB, uploaded 29 May 2019]
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Abstract

Urinary catheterization can cause catheter-related bladder discomfort (CRBD). Ketorolac is widely used for pain control. Therefore, we evaluated the effect of ketorolac on the prevention of CRBD in patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP). All patients were randomly allocated to the ketorolac group or the control group. The primary outcome was CRBD above a moderate grade at 0 h postoperatively. CRBD above a moderate grade at 1, 2, and 6 h was also assessed. Postoperative pain, opioid requirement, ketorolac-related complications, patient satisfaction, and hospitalization duration were also assessed. The incidence of CRBD above a moderate grade at 0 h postoperatively was significantly lower in the ketorolac group (21.5% vs. 50.8%, p = 0.001) as were those at 1, 2, and 6 h. Pain scores at 0 and 1 h and opioid requirement over 24 h were significantly lower in the ketorolac group, while patient satisfaction scores were significantly higher in the ketorolac group. Ketorolac-related complications and hospitalization duration were not significantly different between the two groups. This study shows ketorolac can reduce postoperative CRBD above a moderate grade and increase patient satisfaction in patients undergoing RALP, suggesting it is a useful option to prevent postoperative CRBD. View Full-Text
Keywords: catheter-related bladder discomfort; ketorolac; robot-assisted laparoscopic prostatectomy catheter-related bladder discomfort; ketorolac; robot-assisted laparoscopic prostatectomy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Park, J.-Y.; Hong, J.H.; Yu, J.; Kim, D.-H.; Koh, G.-H.; Lee, S.-A.; Hwang, J.-H.; Kong, Y.-G.; Kim, Y.-K. Effect of Ketorolac on the Prevention of Postoperative Catheter-Related Bladder Discomfort in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy: A Randomized, Double-Blinded, Placebo-Controlled Study. J. Clin. Med. 2019, 8, 759.

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