Next Article in Journal
High Normal Range of Free Thyroxine is Associated with Decreased Triglycerides and with Increased High-Density Lipoprotein Cholesterol Based on Population Representative Data
Next Article in Special Issue
Snail-Overexpression Induces Epithelial-mesenchymal Transition and Metabolic Reprogramming in Human Pancreatic Ductal Adenocarcinoma and Non-tumorigenic Ductal Cells
Previous Article in Journal
Thyroid Hormones and Spermatozoa: In Vitro Effects on Sperm Mitochondria, Viability and DNA Integrity
Previous Article in Special Issue
Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape
Open AccessReview

Snail1: A Transcriptional Factor Controlled at Multiple Levels

1
Programa de Recerca en Càncer, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Unidad Asociada al CSIC, 08003 Barcelona, Spain
2
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(6), 757; https://doi.org/10.3390/jcm8060757
Received: 7 May 2019 / Revised: 23 May 2019 / Accepted: 23 May 2019 / Published: 28 May 2019
Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this review, we describe the different elements that control Snail1 expression and its activity both as transcriptional repressor or activator. View Full-Text
Keywords: Snail1; transcriptional factor; Epithelial to mesenchymal transition (EMT); tumor invasion; drug resistance Snail1; transcriptional factor; Epithelial to mesenchymal transition (EMT); tumor invasion; drug resistance
Show Figures

Figure 1

MDPI and ACS Style

Baulida, J.; Díaz, V.M.; García de Herreros, A. Snail1: A Transcriptional Factor Controlled at Multiple Levels. J. Clin. Med. 2019, 8, 757.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop