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When a Slice Is Not Enough! Comparison of Whole-Brain versus Standard Limited-Slice Perfusion Computed Tomography in Patients with Severe Traumatic Brain Injury

1
Department of Traumatology, John Hunter Hospital, Newcastle 2300, Australia
2
Faculty of Medicine, University of Newcastle, Newcastle 2300, Australia
3
Department of Neurology, Royal Melbourne Hospital, Victoria 3050, Australia
4
Faculty of Medicine, University of Melbourne, Melbourne 3050, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 701; https://doi.org/10.3390/jcm8050701
Received: 15 March 2019 / Revised: 6 May 2019 / Accepted: 16 May 2019 / Published: 17 May 2019
(This article belongs to the Section Neuroscience)
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Abstract

Introduction: Cerebral perfusion computed tomography (PCT) provides crucial information in acute stroke and has an increasing role in traumatic brain injury (TBI) management. Most studies on TBI patients utilize 64-slice scanners, which are limited to four brain slices (limited-brain PCT, LBPCT). Newer 320-slice scanners depict the whole brain perfusion status (WBPCT). We aimed to identify the additional information gained with WBPCT when compared to LBPCT. Patients and methods: Forty-nine patients with severe TBI were investigated within 48 h from admission with WBPCT. Findings from LBPCT were compared with findings from WBPCT. Results: A perfusion abnormality was identified in 39 (80%) and 37 (76%) patients by WBPCT and LBPCT, respectively (p = 0.8). There were 90 and 68 perfusion abnormalities identified by WBPCT and LBPCT, respectively (p < 0.001). In the 39 patients with a perfusion abnormality detected by WBPCT, 15 (38%) had further perfusion abnormalities outside the LBPCT area of coverage. Thirty-six (92%) patients had a larger perfusion abnormality upon WBPCT compared with LBPCT. Additional information gained showed some statistically significant correlation with clinical outcome. Conclusions: In severe TBI patients, WBPCT provides extra information compared to LBPC. The limitations of LBPCT should be considered when evaluating studies reporting on PCT findings and their association with outcomes. View Full-Text
Keywords: severe traumatic brain injury; perfusion computed tomography; PCT severe traumatic brain injury; perfusion computed tomography; PCT
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Cooper, S.; Bendinelli, C.; Bivard, A.; Parsons, M.; Balogh, Z.J. When a Slice Is Not Enough! Comparison of Whole-Brain versus Standard Limited-Slice Perfusion Computed Tomography in Patients with Severe Traumatic Brain Injury. J. Clin. Med. 2019, 8, 701.

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