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Open AccessArticle

Association between Sarcopenia and Depression in Patients with Chronic Liver Diseases

Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 634;
Received: 17 April 2019 / Revised: 7 May 2019 / Accepted: 7 May 2019 / Published: 8 May 2019
(This article belongs to the Section Psychiatry)
Association between sarcopenia, as evaluated by grip strength (GS) and skeletal muscle mass (SMM), and depression, as evaluated by Beck Depression Inventory-2nd edition (BDI-II) in chronic liver diseases (CLDs, n = 414, average age = 61.5 years), was investigated. Study subjects were classified into four groups: Group A (n = 60), lower GS and lower SMM (sarcopenia); group B (n = 44), lower GS and higher SMM; group C (n = 100), higher GS and lower SMM; group D (n = 210), higher GS and higher SMM. Factors associated with BDI-II score ≥11 were examined. BDI-II score 0–10 (normal) was found in 284 (68.6%), 11–16 (minimal) in 76 (18.4%), 17–20 (mild) in 24 (5.8%), 21–30 (moderate) in 15 (3.6%), and ≥31 (severe) in 15 (3.6%). The average ± standard deviation BDI-II score in liver cirrhosis (LC) patients (10.2 ± 9.6, n = 152) was significantly higher than that in non-LC patients (7.4 ± 7.2, n = 262) (p = 0.0058). Univariate analysis identified three factors to be significantly associated with BDI-I score ≥11: Our classification (groups of A, B, C, and D) (p = 0.0259), serum albumin (p = 0.0445), and the presence of LC (p = 0.0157). Multivariate analysis revealed that only group A (p = 0.0074, group D as a reference) was significant. In conclusion, sarcopenia can be an independent predictor for depression in CLDs. View Full-Text
Keywords: chronic liver disease; sarcopenia; depression; beck depression inventory chronic liver disease; sarcopenia; depression; beck depression inventory
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Nishikawa, H.; Enomoto, H.; Yoh, K.; Iwata, Y.; Sakai, Y.; Kishino, K.; Ikeda, N.; Takashima, T.; Aizawa, N.; Takata, R.; Hasegawa, K.; Ishii, N.; Yuri, Y.; Nishimura, T.; Iijima, H.; Nishiguchi, S. Association between Sarcopenia and Depression in Patients with Chronic Liver Diseases. J. Clin. Med. 2019, 8, 634.

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