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Open AccessArticle

Increased Arterial Stiffness in Prediabetic Subjects Recognized by Hemoglobin A1c with Postprandial Glucose but Not Fasting Glucose Levels

by 1,2, 2,3, 2,3, 1,2,3,* and 2,3,*
1
Department of Health Management Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan
2
Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan
3
Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(5), 603; https://doi.org/10.3390/jcm8050603
Received: 9 March 2019 / Revised: 24 April 2019 / Accepted: 30 April 2019 / Published: 1 May 2019
(This article belongs to the Special Issue Clinical Research on Diabetic Complications)
Previous studies exploring the association between arterial stiffness and prediabetes remain controversial. This study aimed to investigate the association of the different domains of prediabetes categorized by glycated hemoglobin A1c (A1c) 5.7–6.4%, impaired fasting glucose (IFG), fasting plasma glucose of 5.6–6.9 mmol/L, and impaired glucose tolerance (IGT), two-hour post-load glucose of 7.8–11.0 mmol/L, on arterial stiffness. These were measured by brachial–ankle pulse-wave velocity (baPWV). We enrolled 4938 eligible subjects and divided them into the following nine groups: (1) normoglycemic; (2) isolated A1c 5.7–6.4%; (3) isolated IFG; (4) IFG with A1c 5.7–6.4%; (5) isolated IGT; (6) combined IGT and IFG with A1c <5.7%; (7) IGT with A1c 5.7–6.4%; (8) combined IGT and IFG with A1c 5.7–6.4%; and (9) newly diagnosed diabetes (NDD). The baPWV values were significantly high in subjects with NDD (β = 47.69, 95% confidence interval (CI) = 29.02–66.37, p < 0.001), those with IGT with A1c 5.7–6.4% (β = 36.02, 95% CI = 19.08–52.95, p < 0.001), and those with combined IGT and IFG with A1c 5.7–6.4% (β = 27.72, 95% CI = 0.68–54.76, p = 0.044), but not in the other subgroups. These findings suggest that increased arterial stiffness was found in prediabetes individuals having an A1c 5.7–6.4% with IGT, but not IFG. Isolated A1c 5.7–6.4% and isolated IGT were not associated with elevated arterial stiffness. View Full-Text
Keywords: prediabetes; arterial stiffness; baPWV prediabetes; arterial stiffness; baPWV
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MDPI and ACS Style

Li, C.-H.; Lu, F.-H.; Yang, Y.-C.; Wu, J.-S.; Chang, C.-J. Increased Arterial Stiffness in Prediabetic Subjects Recognized by Hemoglobin A1c with Postprandial Glucose but Not Fasting Glucose Levels. J. Clin. Med. 2019, 8, 603. https://doi.org/10.3390/jcm8050603

AMA Style

Li C-H, Lu F-H, Yang Y-C, Wu J-S, Chang C-J. Increased Arterial Stiffness in Prediabetic Subjects Recognized by Hemoglobin A1c with Postprandial Glucose but Not Fasting Glucose Levels. Journal of Clinical Medicine. 2019; 8(5):603. https://doi.org/10.3390/jcm8050603

Chicago/Turabian Style

Li, Chung-Hao; Lu, Feng-Hwa; Yang, Yi-Ching; Wu, Jin-Shang; Chang, Chih-Jen. 2019. "Increased Arterial Stiffness in Prediabetic Subjects Recognized by Hemoglobin A1c with Postprandial Glucose but Not Fasting Glucose Levels" J. Clin. Med. 8, no. 5: 603. https://doi.org/10.3390/jcm8050603

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