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The Ideal Goal of Testosterone Replacement Therapy: Maintaining Testosterone Levels or Managing Symptoms?

Evolution of Guidelines for Testosterone Replacement Therapy

Department of Urology and Medical Research Institute of Pusan National University Hospital, Pusan National University School of Medicine, Busan 49241, Korea
Department of Urology, Korea University Guro Hospita, l No. 148, Gurodong-ro, Guro-gu, Seoul 08308, Korea
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(3), 410;
Received: 16 March 2019 / Accepted: 20 March 2019 / Published: 25 March 2019
(This article belongs to the Special Issue Testosterone and Men’s Health: From Evidence to Clinical Practice)
Testosterone is an essential hormone required for the developmental growth and maintenance of the male phenotype during the whole life. With the increasing male life expectancy worldwide and development of adequate testosterone preparations, the prescription of testosterone has increased tremendously. Testosterone replacement should be based on low serum testosterone and related clinical symptoms. In the last two decades, with the accumulation of data, official recommendations have evolved in terms of definition, diagnosis, treatment, and follow-up. In practice, it is better for physicians to follow the Institutional Official Recommendations or Clinical Practice Guideline for an adequate diagnosis and treatment of testosterone deficiency. Currently, four official recommendations are available for diagnosis and treatment of patients with testosterone deficiency. The inconsistencies in the guidelines merely create confusion among the physicians instead of providing clear information. Furthermore, there is no definite method to assess serum testosterone and clinical symptoms. In the era of active testosterone replacement therapy (TRT), physicians’ practice patterns should be consistent with the clinical practice guidelines to avoid the misuse of testosterone. In this review, the author introduces the evolution of clinical guidelines to provide a comprehensive understanding of the differences and controversies with respect to TRT. View Full-Text
Keywords: testosterone; hypogonadism; men’s health; androgens testosterone; hypogonadism; men’s health; androgens
MDPI and ACS Style

Park, H.J.; Ahn, S.T.; Moon, D.G. Evolution of Guidelines for Testosterone Replacement Therapy. J. Clin. Med. 2019, 8, 410.

AMA Style

Park HJ, Ahn ST, Moon DG. Evolution of Guidelines for Testosterone Replacement Therapy. Journal of Clinical Medicine. 2019; 8(3):410.

Chicago/Turabian Style

Park, Hyun Jun, Sun Tae Ahn, and Du Geon Moon. 2019. "Evolution of Guidelines for Testosterone Replacement Therapy" Journal of Clinical Medicine 8, no. 3: 410.

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